Case Report
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 6, 2020; 8(15): 3372-3376
Published online Aug 6, 2020. doi: 10.12998/wjcc.v8.i15.3372
Facial and bilateral lower extremity edema due to drug-drug interactions in a patient with hepatitis C virus infection and benign prostate hypertrophy: A case report
Ya-Ping Li, Ying Yang, Mu-Qi Wang, Xin Zhang, Wen-Jun Wang, Mei Li, Feng-Ping Wu, Shuang-Suo Dang
Ya-Ping Li, Ying Yang, Mu-Qi Wang, Xin Zhang, Wen-Jun Wang, Mei Li, Feng-Ping Wu, Shuang-Suo Dang, Department of Infectious Diseases, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
Author contributions: Li YP and Yang Y were the patient’s doctor in charge, reviewed the literature and contributed to manuscript drafting; Wang MQ, Zhang X and Wang WJ reviewed the literature and contributed to manuscript drafting; Li M, Wu FP and Dang SS revised the manuscript for important intellectual content; all authors issued final approval for the version to be submitted.
Supported by the National Natural Science Foundation of China, No. 81701632; Shanxi Province Social Development Project, No. 2018SF-269.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Shuang-Suo Dang, PhD, Professor, Department of Infectious Diseases, Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 Xiwu Road, Xincheng District, Xi'an 710004, Shaanxi Province, China. dangshuangsuo123@xjtu.edu.cn
Received: March 18, 2020
Peer-review started: March 18, 2020
First decision: April 22, 2020
Revised: June 7, 2020
Accepted: July 16, 2020
Article in press: July 16, 2020
Published online: August 6, 2020
Core Tip

Core tip: In this manuscript, we report a case of drug-drug interaction in a 46-year-old man who was diagnosed with hepatitis C virus infection with benign prostatic hypertrophy. The patient received sofosbuvir/velpatasvir as well as methadone maintenance therapy for drug abuse. The viral load became negative at week 1 post treatment. He developed facial and bilateral lower extremity edema 48 h after starting receiving tamsulosin. Edema disappeared 10 d after treatment with oral furosemide and spironolactone. This case could be useful in clinical management of patients with hepatitis C virus infection, and clinicians should be aware of drug-drug interactions in this subset of patients.