Copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 6, 2020; 8(15): 3334-3340
Published online Aug 6, 2020. doi: 10.12998/wjcc.v8.i15.3334
Published online Aug 6, 2020. doi: 10.12998/wjcc.v8.i15.3334
Coexistence of ovarian serous papillary cystadenofibroma and type A insulin resistance syndrome in a 14-year-old girl: A case report
Fang-Fang Yan, Bing-Kun Huang, Yin-Ling Chen, Chang-Qin Liu, Xue-Jun Li, Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, Xiamen 361003, Fujian Province, China
Yan-Zhen Zhuang, Xue-Ye You, Department of Pathology, The First Affiliated Hospital of Xiamen University, Xiamen 361003, Fujian Province, China
Author contributions: Yan FF and Huang BK wrote the manuscript draft; Chen YL created the figures; Zhuang YZ and You XY conducted the staining and pathological diagnosis; Liu CQ collected the clinical information; Li XJ designed the study and revised the submission; all authors contributed to the discussion and approved the final manuscript for the version to be submitted.
Informed consent statement: Informed written consent was obtained from the father of the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xue-Jun Li, MD, PhD, Chief Doctor, Professor, Department of Endocrinology and Diabetes, the First Affiliated Hospital of Xiamen University, No. 55 Zhenhai Road, Siming District, Xiamen 361003, Fujian Province, China. xmlixuejun@163.com
Received: March 27, 2020
Peer-review started: March 30, 2020
First decision: April 24, 2020
Revised: May 27, 2020
Accepted: July 14, 2020
Article in press: July 14, 2020
Published online: August 6, 2020
Peer-review started: March 30, 2020
First decision: April 24, 2020
Revised: May 27, 2020
Accepted: July 14, 2020
Article in press: July 14, 2020
Published online: August 6, 2020
Core Tip
Core tip: Type A insulin resistance syndrome (TAIRS) is a rare disorder that results from mutations in the gene encoding the insulin receptor. We present a rare case of TAIRS coexisting with an ovarian serous papillary cystadenofibroma in a 14-year-old girl caused by gene mutation. This case demonstrates that metformin has partial efficacy in the treatment of TAIRS. Furthermore, insulin may play a critical role in the development and progression of ovarian cystadenofibroma.