Copyright
©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 26, 2019; 7(22): 3895-3903
Published online Nov 26, 2019. doi: 10.12998/wjcc.v7.i22.3895
Published online Nov 26, 2019. doi: 10.12998/wjcc.v7.i22.3895
Diffuse large B-cell lymphoma arising from follicular lymphoma with warthin’s tumor of the parotid gland - immunophenotypic and genetic features: A case report
Chang-Song Wang, Nian-Long Meng, Xue-Xia Lv, Tian Yun, Yan-Sha Cao, Department of Pathology, 989th Hospital of PLA, Luoyang 471000, Henan Province, China
Xia Chu, Department of Pathology, 988th Hospital of PLA, Zhengzhou 450042, Henan Province, China
Di Yang, Department of Pathology, Sanmenxia center Hospital, Sanmenxia 472000, Henan Province, China
Lei Ren, Department of Pathology, Luoyang First People’s Hospital, Luoyang 471000, Henan Province, China
Author contributions: All of authors made contributions to the acquisition, analysis, or interpretation of data. Wang CS and Yang D were involved in drafting the manuscript and revising it critically for important intellectual content. Wang CS and Chu X were responsible for literature search and manuscript preparation. Yun T, Lv XX and Ren L participated in the discussion for histological diagnosis and manuscript preparation. Meng NL collected the clinical data and postoperative clinical follow-up of the patient. Lv XX and Cao YS participated in the microscopic analyses. All authors read and approved the final manuscript.
Informed consent statement: Written informed consent was obtained from the family members of the patient for publication of this article and any accompanying images.
Conflict-of-interest statement: All authors declare that they have no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2013), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Chang-Song Wang, MD, PhD, Professor, Department of Pathology, 989th Hospital of PLA, No. 2 Huaxia West Road, Luoyang 471031, Henan Province, China. wangtmmu150@163.com
Telephone: +86-379-64169432 Fax: +86-379-64169435
Received: August 1, 2019
Peer-review started: August 1, 2019
First decision: August 9, 2019
Revised: September 23, 2019
Accepted: October 5, 2019
Article in press: October 5, 2019
Published online: November 26, 2019
Peer-review started: August 1, 2019
First decision: August 9, 2019
Revised: September 23, 2019
Accepted: October 5, 2019
Article in press: October 5, 2019
Published online: November 26, 2019
Core Tip
Core tip: We present a case of diffuse large B cell lymphoma (DLBCL) that was transformed from follicular lymphoma in a Warthin’s tumor (WT) excision specimen. This is a very rare lesion with an extremely low incidence and unclear biological behavior. Therefore, we should carefully examine the tumor stroma during the pathological examination because the neoplastic cells can be confused with the normal reactive lymphoid component in WT. Requisite molecular detections are performed when the diagnosis of lymphoma with WT is dubious.