Observational Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 6, 2019; 7(19): 2963-2975
Published online Oct 6, 2019. doi: 10.12998/wjcc.v7.i19.2963
Changes of serum inflammatory factors and miR-145 expression in patients with osteoarthritis before and after treatment and their clinical value
Xiao-Zhen Wang, Wen-Xue Li
Xiao-Zhen Wang, Wen-Xue Li, Department of Orthopedics, Dongying Shengli Hospital, Bei'er Road, Dongying 257055, Shandong Province, China
Author contributions: Li WX designed the research; Wang XZ performed the research, contributed new reagents and analytic tools, analyzed the data, and wrote the paper.
Institutional review board statement: The study was authorized by the Dongying Shengli Hospital.
Conflict-of-interest statement: There was no competing interest.
Data sharing statement: All the data in the current research are available from the corresponding author upon reasonable request.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Wen-Xue Li, BMed, Doctor, Department of Orthopedics, Dongying Shengli Hospital, Bei'er Road, Dongying 257055, Shandong Province, China. maso2518@163.com
Telephone: +86-147-86634801 Fax: +86-546-8569854
Received: July 2, 2019
Peer-review started: July 14, 2019
First decision: August 2, 2019
Revised: August 9, 2019
Accepted: August 20, 2019
Article in press: August 20, 2019
Published online: October 6, 2019
Core Tip

Core tip: At present, the clinical evaluation of osteoarthritis relies on VAS score, Lysholm score, and WOMAC score and other scales. These scales have a common deficiency, i.e., they are affected by a certain degree of subjective factors. Many clinical workers use Kellgren-Lawrence (K-L) grading to evaluate the therapeutic effect of patients with osteoarthritis, but the K-L grading depends on imaging, the effect of radiation on the human body and the medical expenses are high, and it takes a long time. This study explored the clinical value of miR-145 and inflammatory factors in peripheral blood, and explored the application of serological analysis in the diagnosis and treatment of osteoarthritis, so as to provide a reference for the diagnosis and treatment of osteoarthritis.