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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 26, 2019; 7(16): 2189-2203
Published online Aug 26, 2019. doi: 10.12998/wjcc.v7.i16.2189
Published online Aug 26, 2019. doi: 10.12998/wjcc.v7.i16.2189
Serological investigation of IgG and IgE antibodies against food antigens in patients with inflammatory bowel disease
Hai-Yang Wang, Yi Li, Department of Gastroenterology, The Affiliated Sir Run Run Hospital, Nanjing Medical University, Nanjing 211100, Jiangsu Province, China
Hai-Yang Wang, Jia-Jia Li, Chun-Hua Jiao, Xiao-Jing Zhao, Xue-Ting Li, Mei-Jiao Lu, Xia-Qiong Mao, Hong-Jie Zhang, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Author contributions: Wang HY and Zhang HJ designed the study; Li Y, Jiao CH, Zhao XJ, Li XT, Lu MJ and Mao XQ collected specimens; Wang HY and Li Y performed the research; Wang HY and Li JJ analyzed the data; Wang HY wrote this manuscript; Zhang HJ supervised the report.
Supported by the National Natural Science Foundation of China , No. 81770553 ; and Science and Technology Development Fund of Nanjing Medical University , No. NMUB2018291 .
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the First Affiliated Hospital of Nanjing Medical University.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors declare no conflicts of interest related to this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hong-Jie Zhang, PhD, Chief Physician, Professor, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. hjzhang06@163.com
Telephone: +86-25-83718836 Fax: +86-25-83674636
Received: April 12, 2019
Peer-review started: April 12, 2019
First decision: May 16, 2019
Revised: June 21, 2019
Accepted: July 3, 2019
Article in press: July 3, 2019
Published online: August 26, 2019
Peer-review started: April 12, 2019
First decision: May 16, 2019
Revised: June 21, 2019
Accepted: July 3, 2019
Article in press: July 3, 2019
Published online: August 26, 2019
Core Tip
Core tip: Food antigens have been indicated to participate in the etiopathogenesis of inflammatory bowel disease. However, their value is disputable, as some studies found that food immunoglobulin G (IgG) and E (IgE) antibodies can be expressed in healthy individuals. This study analyzed the levels of specific IgG and IgE antibodies against food antigens in inflammatory bowel disease patients and found that Crohn’s disease patients not only have higher prevalence of food-specific IgG, but also intolerance against rice, corn, tomato and soybean.