Basic Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 6, 2019; 7(15): 1954-1963
Published online Aug 6, 2019. doi: 10.12998/wjcc.v7.i15.1954
Vestigial like family member 3 is a novel prognostic biomarker for gastric cancer
Li-Hua Zhang, Zhuo Wang, Long-Hai Li, Yan-Kui Liu, Lin-Fang Jin, Xiao-Wei Qi, Chun Zhang, Teng Wang, Dong Hua
Li-Hua Zhang, Dong Hua, School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, Jiangsu Province, China
Li-Hua Zhang, Teng Wang, Dong Hua, Department of Oncology, Affiliated Hospital of Jiangnan University, Wuxi 214062, Jiangsu Province, China
Zhuo Wang, Department of Geriatrics, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi 214023, Jiangsu Province, China
Long-Hai Li, Chun Zhang, Wuxi Medical College, Jiangnan University, Wuxi 214122, Jiangsu Province, China
Yan-Kui Liu, Lin-Fang Jin, Xiao-Wei Qi, Department of Pathology, Affiliated Hospital of Jiangnan University, Wuxi 214062, Jiangsu Province, China
Author contributions: Zhang LH and Wang Z contributed equally to this work; Wang T and Hua D designed the research; Li LH, Liu YK, Jin LF, Qi XW, and Zhang C performed the research; Wang T and Hua D contributed new reagents and analytic tools; Li LH, Zhang LH, and Wang Z analyzed the data; Zhang LH and Wang Z wrote the paper.
Supported by the Natural Science Foundation of Jiangsu Province, No. BK20171150; the National Natural Science Foundation of China, No. 81502042; Research Project of Health and Family Planning Commission of Wuxi, No. Q201758; and Nanchang Hongda Jianghua Educational Foundation.
Institutional review board statement: This study was reviewed and approved by Affiliated Hospital of Jiangnan University Institutional Review Board.
Informed consent statement: Any personal item or information will not be published without explicit consent from the involved persons.
Conflict-of-interest statement: The authors report no conflicts of interest in this work.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Dong Hua, MD, PhD, Chief Doctor, Professor, Department of Oncology, Affiliated Hospital of Jiangnan University, No. 200, Huihe Road, Wuxi 214062, Jiangsu Province, China. wx89211@163.com
Telephone: +86-510-88682109 Fax: +86-510-85808820
Received: March 22, 2019
Peer-review started: March 22, 2019
First decision: May 13, 2019
Revised: June 22, 2019
Accepted: July 3, 2019
Article in press: July 3, 2019
Published online: August 6, 2019
Core Tip

Core tip: The present study for the first time revealed the expression of vestigial like family member 3 (VGLL3) in gastric cancer (GC) and its correlation with HER2 mutation. Overall, the findings of the present study suggest that VGLL3 is a novel prognostic biomarker for GC and highlight the significance of VGLL3 as a promising therapeutic target for GC.