Copyright
©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 16, 2017; 5(6): 222-233
Published online Jun 16, 2017. doi: 10.12998/wjcc.v5.i6.222
Published online Jun 16, 2017. doi: 10.12998/wjcc.v5.i6.222
Duodenal gangliocytic paraganglioma with lymph node metastases: A case report and comparative review of 31 cases
Sahara J Cathcart, Department of Pathology and Microbiology, 985900 Nebraska Medical Center, Omaha, NE 68198-5900, United States
Aaron R Sasson, Department of Surgery, Division of Surgical Oncology, Stony Brook Medicine, Stony Brook, NY 11794, United States
Jessica A Kozel, Midwest Pathology Associates, LLC, Overland Park, KS 66210, United States
Jennifer M Oliveto, Department of Radiology, University of Nebraska Medical Center, Omaha, NE 68198, United States
Quan P Ly, Department of Surgery, Division of Surgical Oncology, University of Nebraska Medical Center, Omaha, NE 68198, United States
Author contributions: Cathcart SJ read the literature, compiled review data, wrote the first draft of the paper, and repeatedly edited the manuscript; Sasson AR was the treating surgical oncologist and participated in idea and early revisions of the paper; Kozel JA was the treating surgical pathologist and participated in the idea and early revisions of the paper, as well as provided photographs of the gross and microscopic findings; Oliveto JM assisted in reviewing remote and preoperative imaging and provided photographs of CT imaging; Ly QP repeatedly reviewed the manuscript, made surgical recommendations, and approved the final version.
Institutional review board statement: This case report was exempt from the Institutional Review Board standards at the University of Nebraska Medical Center.
Informed consent statement: The patient involved in this study gave his verbal informed consent authorizing use and disclosure of his protected health information.
Conflict-of-interest statement: All authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sahara J Cathcart, MD, Resident, Department of Pathology and Microbiology, 985900 Nebraska Medical Center, Omaha, NE 68198-5900, United States. sahara.cathcart@unmc.edu
Telephone: +1-402-5593456 Fax: +1-402-5596018
Received: December 5, 2016
Peer-review started: December 6, 2016
First decision: January 13, 2017
Revised: February 14, 2017
Accepted: April 23, 2017
Article in press: April 24, 2017
Published online: June 16, 2017
Peer-review started: December 6, 2016
First decision: January 13, 2017
Revised: February 14, 2017
Accepted: April 23, 2017
Article in press: April 24, 2017
Published online: June 16, 2017
Core Tip
Core tip: Duodenal gangliocytic paragangliomas (GP) generally behave in a benign manner, but infrequently lymph node, and rarely distant, metastases occur. Even in such cases, prognosis remains excellent with only a single reported disease-related death. Here we report a patient with a duodenal GP with regional lymph node metastases and review the literature to help direct management of the rare tumor. In reviewing the literature, achieving complete resection of primary tumor and positive lymph nodes appears to be curative. As such, this should be the therapeutic goal in surgically fit patients.