Role of nitric oxide, prostaglandins, thromboxanes and endothelins in lung cancer: An overview

doi:10.12998/wjcc.v13.i25.107907

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Sep 6, 2025 (publication date) through Jul 7, 2025

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Sep 6, 2025; 13(25): 107907
Published online Sep 6, 2025. doi: 10.12998/wjcc.v13.i25.107907

Role of nitric oxide, prostaglandins, thromboxanes and endothelins in lung cancer: An overview

Sadettin Demirel, Ipek Nazli Sinag

Sadettin Demirel, Ipek Nazli Sinag, Medicine School, Physiology Department, Bursa Uludag University, Bursa 16059, Türkiye

Author contributions: Demirel S designed the project and wrote the manuscript; Sinag IN performed a literature search and wrote the manuscript. All authors have read and approved the final manuscript.

Conflict-of-interest statement: The authors declare no financial or other conflicts of interest.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Sadettin Demirel, PhD, Associate Professor, Medicine School, Physiology Department, Bursa Uludag University, Nilufer, Bursa 16059, Türkiye. sdemirel@uludag.edu.tr

Received: April 2, 2025
Revised: April 15, 2025
Accepted: May 26, 2025
Published online: September 6, 2025
Processing time: 98 Days and 9.9 Hours

Core Tip

Core Tip: Lung cancer remains the leading cause of cancer-related deaths globally. Nitric oxide (NO), prostaglandins (PGs), thromboxanes (TXs), and endothelins (ETs) significantly influence lung carcinogenesis by modulating cancer cell proliferation, apoptosis, invasion, and angiogenesis. This study highlights the dual roles of NO, the opposing effects of arachidonic acid-derived PGs, the involvement of TXA₂ and its metabolite TXB₂, and the critical functions of ETs in lung cancer progression. The findings emphasize the complex interplay of these agents in tumor biology, offering insights for potential therapeutic targets.