Tramadol overdose in total knee arthroplasty: A case report

doi:10.12998/wjcc.v13.i25.104742

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World Journal of Clinical Cases

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Report

World J Clin Cases. Sep 6, 2025; 13(25): 104742
Published online Sep 6, 2025. doi: 10.12998/wjcc.v13.i25.104742

Tramadol overdose in total knee arthroplasty: A case report

Bushu Harna, Shivali Arya

Bushu Harna, Department of Orthopaedics, Indus International Hospital, Mohali 140507, Punjab, India

Shivali Arya, Department of Radiology, Lifetree Healthcare, Zirakpur 140603, Punjab, India

Co-first authors: Bushu Harna and Shivali Arya.

Author contributions: Harna B and Arya S wrote manuscript and contributed equally to this manuscript as co-first authors. Harna B collected data; Arya S read proof.

Informed consent statement: Informed consent was taken from the patient for publishing the data.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Bushu Harna, MD, Department of Orthopaedics, Indus International Hospital, No. 22 Ambala Road, Dera Bassi, Mohali 160507, Punjab, India. bushu.edu@gmail.com

Received: December 31, 2024
Revised: April 27, 2025
Accepted: May 21, 2025
Published online: September 6, 2025
Processing time: 188 Days and 21.9 Hours

Core Tip

Core Tip: Clinicians should be aware of opioid toxicity in total knee arthroplasty patients. Cautions should be taken in the presence of kidney disorders. Tramadol and buprenorphine patches were commonly utilized in postoperative analgesia of knee arthroplasty. The combination of these drugs was not recommended and should be monitored for any adverse effects. It is better to use pre-emptive analgesia with minimum use of opioids.