Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 26, 2024; 12(6): 1094-1103
Published online Feb 26, 2024. doi: 10.12998/wjcc.v12.i6.1094
Assessment of the triglyceride glucose index in adult patients with chronic diarrhea and constipation
Jing-Yi Zhu, Mu-Yun Liu, Chang Sun
Jing-Yi Zhu, Chang Sun, Department of Gastroenterology, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China
Mu-Yun Liu, Department of Gastroenterology, Navy No. 905 Hospital, Naval Medical University, Shanghai 200433, China
Author contributions: All contributors participated in study formulation and design. Zhu JY prepared the initial draft of the manuscript; Liu MY prepared, collected, and analyzed the data; Sun C revised and reviewed the manuscript; the manuscript was accepted for publication after final approval from the authors.
Institutional review board statement: The NHANES is a publicly available database, and this research was reviewed and approved by the Research Ethics Review Board of the National Center for Health Statistics.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
Data sharing statement: The dataset supporting the conclusions of this article is available in the NHANES repository: NHANES-National Health and Nutrition Examination Survey Homepage (
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Chang Sun, MD, Associate Professor, Department of Gastroenterology, The First Affiliated Hospital of Naval Medical University, No. 168 Changhai Road, Shanghai 200433, China.
Received: December 8, 2023
Peer-review started: December 8, 2023
First decision: December 20, 2023
Revised: January 3, 2024
Accepted: January 19, 2024
Article in press: January 19, 2024
Published online: February 26, 2024
Core Tip

Core Tip: Chronic diarrhea and constipation are two common conditions that interfere with daily life. Herein, we identified a positive association between the triglyceride glucose index, a marker of insulin resistance (IR), and chronic diarrhea in the National Health and Nutrition Examination Survey database. These results suggest that early and comprehensive management of IR may be beneficial for maintaining normal bowel health. Further investigations should be conducted on the underlying pathological mechanisms.