Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 26, 2023; 11(9): 2067-2073
Published online Mar 26, 2023. doi: 10.12998/wjcc.v11.i9.2067
Live births from in vitro fertilization-embryo transfer following the administration of gonadotropin-releasing hormone agonist without gonadotropins: Two case reports
Mai Li, Ping Su, Li-Ming Zhou
Mai Li, Li-Ming Zhou, Reproductive Center, Ningbo Women and Children’s Hospital, Ningbo 315000, Zhejiang Province, China
Ping Su, Reproductive Center, Institution of Reproductive Health, Tongji Medical College, Wuhan 430030, Hubei Province, China
Author contributions: Li M contributed significantly to case collections and analysis and wrote the manuscript; Zhou LM contributed to the conception of the study; Su P contributed to manuscript preparation.
Informed consent statement: Informed written consent was obtained from the patients.
Conflict-of-interest statement: The authors declare having no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Li-Ming Zhou, BMed, Chief Physician, Reproductive Center, Ningbo Women and Children’s Hospital, No. 339 Liuting Street, Ningbo 315000, Zhejiang Province, China.
Received: December 13, 2022
Peer-review started: December 13, 2022
First decision: January 20, 2023
Revised: March 1, 2023
Article in press: March 1, 2023
Published online: March 26, 2023
Core Tip

Core Tip: Gonadotropin-releasing hormone agonist (GnRHa) is administered in the ‘long protocol’ regimen for pituitary downregulation in vitro fertilization-embryo transfer. The development of ovarian cysts requires gonadotropin administration after pituitary downregulation in the long protocol. However, our cases presented an extremely special condition that a very small group of patients can develop called ovarian hyperstimulation receiving GnRHa alone. It is extremely rare that both patients had a successful egg retrieval during their first in vitro fertilization cycle and were impregnated. These cases provide some experience for clinical judgment and a new insight into the possible mechanisms of GnRHa action without gonadotropins.