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World J Clin Cases. Mar 26, 2023; 11(9): 1918-1929
Published online Mar 26, 2023. doi: 10.12998/wjcc.v11.i9.1918
COVID-19 related liver injuries in pregnancy
Metodija Sekulovski, Simona Bogdanova-Petrova, Monika Peshevska-Sekulovska, Tsvetelina Velikova, Tsvetoslav Georgiev
Metodija Sekulovski, Department of Anesthesiology and Intensive Care, University Hospital Lozenetz, Sofia 1407, Bulgaria
Metodija Sekulovski, Monika Peshevska-Sekulovska, Tsvetelina Velikova, Medical Faculty, Sofia University St. Kliment Ohridski, Sofia 1407, Bulgaria
Simona Bogdanova-Petrova, Tsvetoslav Georgiev, First Department of Internal Medicine, Medical University-Varna, Varna 9010, Bulgaria
Simona Bogdanova-Petrova, Tsvetoslav Georgiev, Clinic of Rheumatology, University Hospital “St. Marina”, Varna 9010, Bulgaria
Monika Peshevska-Sekulovska, Department of Gastroenterology, University Hospital Lozenetz, Sofia 1407, Bulgaria
Tsvetelina Velikova, Department of Clinical Immunology, University Hospital Lozenetz, Sofia 1407, Bulgaria
Author contributions: Georgiev T and Sekulovski M contributed to the conceptualization; Georgiev T Sekulovski M, Bogdanova-Petrova S and Peshevska-Sekulovska M contributed to the resources and literature review; Georgiev T, Sekulovski M, Bogdanova-Petrova S and Peshevska-Sekulovska M contributed to the preparation of original draft; Georgiev T, Sekulovski M, Velikova T contributed to the review and editing; Georgiev T, and Velikova T contributed to the supervision; All authors revised and approved the final version of the manuscript.
Conflict-of-interest statement: The authors declare they have no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tsvetoslav Georgiev, MD, PhD, Associate Professor, First Department of Internal Medicine, Medical University-Varna, 1 Hristo Smirnenski str., Varna 9010, Bulgaria. tsetso@medfaculty.org
Received: November 22, 2022
Peer-review started: November 22, 2022
First decision: January 3, 2023
Revised: January 17, 2023
Accepted: February 21, 2023
Article in press: February 21, 2023
Published online: March 26, 2023
Core Tip

Core Tip: Angiotensin-converting enzyme 2 receptors are expressed in hepatocytes and cholangiocytes, suggesting the potential for liver involvement by coronavirus disease 2019 (COVID-19). Liver dysfunction is mainly observed in patients with severe or critical disease. However, little is known about the course of liver involvement and its sequelae in pregnant women positive for severe acute respiratory syndrome coronavirus 2. Several cases of hepatic injury in pregnant women with severe COVID-19 have been reported, making the liver the second most commonly affected organ following the lung.