Xia Y, Liu H, Zhu R. Analysis of differentially expressed genes related to cerebral ischaemia in young rats based on the Gene Expression Omnibus database. World J Clin Cases 2023; 11(7): 1467-1476 [PMID: 36926408 DOI: 10.12998/wjcc.v11.i7.1467]
Corresponding Author of This Article
Rui Zhu, MD, Chief Physician, Department of Neurology, The Third People’s Hospital of Hefei (The Third Clinical College of Anhui Medical University), No. 204 Wangjiang East Road, Hefei 230022, Anhui Province, China. masterzr117@sina.com
Research Domain of This Article
Neurosciences
Article-Type of This Article
Clinical and Translational Research
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Mar 6, 2023; 11(7): 1467-1476 Published online Mar 6, 2023. doi: 10.12998/wjcc.v11.i7.1467
Analysis of differentially expressed genes related to cerebral ischaemia in young rats based on the Gene Expression Omnibus database
Yu Xia, Han Liu, Rui Zhu
Yu Xia, Rui Zhu, Department of Neurology, The Third People’s Hospital of Hefei (The Third Clinical College of Anhui Medical University), Hefei 230022, Anhui Province, China
Han Liu, Department of Neurology, The First Affiliated Hospital of Anhui Medical University (Anhui Public Health Clinical Center), Hefei 230022, Anhui Province, China
Author contributions: Xia Y and Zhu R designed the research and wrote the paper; Xia Y and Liu H performed the research; Liu H contributed new reagents; Xia Y analyzed the data.
Conflict-of-interest statement: We declare that that there is no conflict of interest to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rui Zhu, MD, Chief Physician, Department of Neurology, The Third People’s Hospital of Hefei (The Third Clinical College of Anhui Medical University), No. 204 Wangjiang East Road, Hefei 230022, Anhui Province, China. masterzr117@sina.com
Received: December 7, 2022 Peer-review started: December 7, 2022 First decision: January 3, 2023 Revised: January 4, 2023 Accepted: February 15, 2023 Article in press: February 15, 2023 Published online: March 6, 2023
Core Tip
Core Tip: This study mainly used the analysis technology related to biogenetic informatics to retrieve the samples of young cerebral ischemia rats from the authoritative global Gene Expression Omnibus database, identified the differential genes related to the onset of cerebral ischemia in young rats through the differential gene analysis method, further carried out Gene Ontology function enrichment analysis and Kyoto Encyclopedia of Genes and Genomes function enrichment analysis, and finally obtained the key gene pathway that affects ischaemic stroke in young rats. The findings provide clues for further realizing the transformation of basic medicine into clinical practical application, so as to finally realize the precise target intervention of young people with ischemic stroke and reduce the disability rate and mortality rate.
