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Hong X, Ji YQ, Chen MY, Gou XY, Ge YM. Nocardia cyriacigeorgica infection in a patient with repeated fever and CD4+ T cell deficiency: A case report. World J Clin Cases 2023; 11(5): 1175-1181 [PMID: 36874428 DOI: 10.12998/wjcc.v11.i5.1175]
World J Clin Cases. Feb 16, 2023; 11(5): 1175-1181 Published online Feb 16, 2023. doi: 10.12998/wjcc.v11.i5.1175
Nocardia cyriacigeorgica infection in a patient with repeated fever and CD4+ T cell deficiency: A case report
Xin Hong, You-Qi Ji, Meng-Yuan Chen, Xiao-Yu Gou, Yu-Mei Ge
Xin Hong, Department of Green Pharmaceutical Collaborative Innovation Center, School of Pharmacy, Zhejiang University of Technology, Hangzhou 310014, Zhejiang Province, China
You-Qi Ji, School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China
Meng-Yuan Chen, The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China
Xiao-Yu Gou, Yu-Mei Ge, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou 310014, Zhejiang Province, China
Author contributions: Hong X, Ji YQ, Chen MY, and Gou XY collect the patient clinical information and analysed the data; Ge YM drawn the manuscript; all authors have read and approved the final manuscript.
Informed consent statement: Written and informed consent was obtained from the patient for publication of this case report and any accompanying images.
Conflict-of-interest statement: All the authors declare that they have no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Received: November 12, 2022 Peer-review started: November 12, 2022 First decision: December 26, 2022 Revised: January 7, 2023 Accepted: January 16, 2023 Article in press: January 16, 2023 Published online: February 16, 2023 Processing time: 93 Days and 21.8 Hours
Core Tip
Core Tip: Patients with CD4+ T-cell deficiency should be aware of Nocardia infection. Nocardia pneumonia shares similar imaging and clinical features with pulmonary tuberculosis and lung neoplasms, but the treatment and anti-infective medication are completely different. Here, we report a case of pulmonary nocardiosis caused by Nocardia cyriacigeorgica (N. cyriacigeorgica), which was misdiagnosed as community-acquired pneumonia with repeated fever. We identified the pathogen by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). The patient used compound sulfamethoxazole tablets (0.96 g) three times a day. After one week of treatment, the infection index returned to normal, the patient's condition improved significantly, and she was discharged.
