Valsamaki A, Xanthoudaki M, Oikonomou KG, Vlachostergios PJ, Papadogoulas A, Katsiafylloudis P, Voulgaridi I, Skoura AL, Komnos A, Papamichalis P. Prevention, diagnostic evaluation, management and prognostic implications of liver disease in critically ill patients with COVID-19. World J Clin Cases 2023; 11(3): 514-527 [PMID: 36793637 DOI: 10.12998/wjcc.v11.i3.514]
Corresponding Author of This Article
Panagiotis Papamichalis, MD, PhD, Consultant Physician-Scientist, Doctor, Intensive Care Unit, General Hospital of Larissa, Tsakalof 1, Larissa 41221, Greece. ppapamih@med.uth.gr
Research Domain of This Article
Critical Care Medicine
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Asimina Valsamaki, Maria Xanthoudaki, Katerina G Oikonomou, Antonios Papadogoulas, Periklis Katsiafylloudis, Apostolos Komnos, Panagiotis Papamichalis, Intensive Care Unit, General Hospital of Larissa, Larissa 41221, Greece
Panagiotis J Vlachostergios, Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, United States
Ioanna Voulgaridi, Department of Microbiology, General Hospital of Larissa, Larissa 41221, Greece
Apostolia-Lemonia Skoura, Transfusion Medicine Department, University Hospital of Larissa, Larissa 41110, Greece
Author contributions: Papamichalis P and Oikonomou KG designed the review; Papadogoulas A, Katsiafylloudis P, Voulgaridi I and Skoura AL gathered the data; Papamichalis P, Oikonomou KG, Valsamaki A and Xanthoudaki M analyzed, interpreted the data and wrote the final version of the manuscript; Oikonomou KG and Vlachostergios PJ performed English editing; Komnos A critically reviewed the paper; All authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors declare having no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Panagiotis Papamichalis, MD, PhD, Consultant Physician-Scientist, Doctor, Intensive Care Unit, General Hospital of Larissa, Tsakalof 1, Larissa 41221, Greece. ppapamih@med.uth.gr
Received: October 12, 2022 Peer-review started: October 12, 2022 First decision: November 26, 2022 Revised: December 5, 2022 Accepted: January 10, 2023 Article in press: January 10, 2023 Published online: January 26, 2023
Core Tip
Core Tip: The liver follows the respiratory system with a lower but considerable frequency of affection by severe acute respiratory syndrome coronavirus 2. Coronavirus disease 2019 causes acute and acute-on-chronic liver injury. The pathophysiological mechanisms are complex. Certain biomarkers such as fibrosis-4 score and non-invasive point-of-care methods such as ultrasonography or transient elastography can be extremely helpful in the early diagnosis of liver injury and the assessment of its progression. Health systems, intensive care units, liver units and transplant programs were seriously affected by the pandemic. The clinician should recognize the symptoms and signs of liver injury early and take the appropriate measures to reverse it.
