Case Control Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 16, 2023; 11(14): 3158-3166
Published online May 16, 2023. doi: 10.12998/wjcc.v11.i14.3158
Changes and significance of serum ubiquitin carboxyl-terminal hydrolase L1 and glial fibrillary acidic protein in patients with glioma
Qing-Hua Zhu, Jing-Kun Wu, Gao-Lei Hou
Qing-Hua Zhu, Jing-Kun Wu, Gao-Lei Hou, Department of Neurosurgery, Affiliated Hospital of Hebei Engineering University, Handan 056002, Hebei Province, China
Author contributions: Zhu QH and Wu JK designed the study, and implemented and collected the data; Zhu QH analyzed the data, wrote and edited the manuscript; and Hou GL supervised and supported the research.
Supported by Hebei Medical Science Research Project, No. 20220648.
Institutional review board statement: This study was approved by the Ethics Committee of the Affiliated Hospital of Hebei Engineering University.
Informed consent statement: All study participants or their legal guardians provided written informed consent prior to study enrollment.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement checklist of items, and the manuscript was prepared and revised according to the STROBE Statement checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing-Kun Wu, MM, Associate Chief Physician, Department of Neurosurgery, Affiliated Hospital of Hebei Engineering University, No. 81 Congtai Street, Congtai District, Handan 056002, Hebei Province, China. wujingkunwjk@163.com
Received: February 19, 2023
Peer-review started: February 19, 2023
First decision: February 28, 2023
Revised: March 17, 2023
Accepted: April 6, 2023
Article in press: April 6, 2023
Published online: May 16, 2023
Core Tip

Core Tip: Since the recurrence rate of glioma is high, it is important to early predict its prognosis. Ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) are important markers for nervous system damages and lesions. Therefore, we evaluated the changes in UCH-L1 and GFAP levels in patients with glioma during the perioperative period and compared them with those in healthy volunteers to analyze their relationship with clinicopathological and postoperative recurrence. These results revealed that UCH-L1 and GFAP might reflect the development and recurrence of glioma and could be used as potential indicators to estimate prognosis of glioma.