Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 16, 2022; 10(35): 13038-13043
Published online Dec 16, 2022. doi: 10.12998/wjcc.v10.i35.13038
Kawasaki disease without changes in inflammatory biomarkers: A case report
Kosei Yamashita, Takeru Kanazawa, Yoshifusa Abe, Takuya Naruto, Masaaki Mori
Kosei Yamashita, Takeru Kanazawa, Yoshifusa Abe, Children’s Medical Center, Showa University Koto Toyosu Hospital, Tokyo 135-8577, Japan
Takuya Naruto, Masaaki Mori, Lifetime Clinical Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan
Masaaki Mori, Department of Rheumatology, Clinical Immunology and Allergology, St. Marianna University School of Medicine, Kanagawa 216-8511, Japan
Author contributions: Yamashita K was the first author of this manuscript; Kanazawa T advised and helped revise the manuscript; Abe Y analyzed the data and drafted the manuscript; Naruto T was measured as leucine-rich alpha-2-glycoprotein; Mori M measured leucine-rich alpha-2-glycoprotein and provided critical comments on the manuscript; all authors have read and approved the final manuscript.
Informed consent statement: Written informed consent was obtained from the patient’s parents for publication of this case report and any accompanying images.
Conflict-of-interest statement: There is no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kosei Yamashita, MD, Doctor, Children’s Medical Center, Showa University Koto Toyosu Hospital, 5-1-38 Toyosu Koto-Ku, Tokyo 135-8577, Japan. meko11115@med.showa-u.ac.jp
Received: August 16, 2022
Peer-review started: August 16, 2022
First decision: October 21, 2022
Revised: November 4, 2022
Accepted: November 18, 2022
Article in press: November 18, 2022
Published online: December 16, 2022
Core Tip

Core Tip: Cases of Kawasaki disease in children with not elevated levels of inflammatory biomarkers, such as C-reactive protein, erythrocyte sedimentation rate, and serum amyloid A protein, are reported. This study clarified the need to identify criteria and biomarkers to detect Kawasaki disease conditions that do not require treatment.