Observational Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 16, 2022; 10(32): 11775-11788
Published online Nov 16, 2022. doi: 10.12998/wjcc.v10.i32.11775
Quality of life and symptom distress after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
Ya-Fen Wang, Ting-Yao Wang, Tzu-Ting Liao, Meng-Hung Lin, Tzu-Hao Huang, Meng-Chiao Hsieh, Vincent Chin-Hung Chen, Li-Wen Lee, Wen-Shih Huang, Chao-Yu Chen
Ya-Fen Wang, Cancer Center, Chang Gung Memorial Hospital, Chiayi, Taiwan
Ting-Yao Wang, Division of Hematology and Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan
Tzu-Ting Liao, Division of Case Management, Cancer Center, Chang Gung Memorial Hospital, Chiayi, Taiwan
Meng-Hung Lin, Health Information and Epidemiology Laboratory, Chang Gung Memorial Hospital, Chiayi, Taiwan
Tzu-Hao Huang, Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan
Meng-Chiao Hsieh, Wen-Shih Huang, Division of Colorectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan
Vincent Chin-Hung Chen, Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi and Chang Gung University, Taoyuan, Taiwan
Li-Wen Lee, Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan
Chao-Yu Chen, Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Chiayi, Taiwan
Chao-Yu Chen, Department of Early Childhood Care and Education, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Chiayi, Taiwan
Author contributions: Wang YF and Wang TY contributed equally to this work; Wang YF, Wang TY, Liao TT, and Chen CY were responsible for the conceptualization, methodology, data curation, and writing—original draft preparation and editing; Lin MH and Wang YF were responsible for the data analysis and software; Huang TH, Chen VCH, Lee LW, Hsieh MC, Huang WS were responsible for resources and supervision; Wang YF received the grants.
Supported by Chang Gung Medical Foundation through grants, No. CMRPG6H0341-43.
Institutional review board statement: The study was reviewed and approved for publication by the Institutional Review Board of Chang Gung Medical Hospital (No. 201800726B0).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author. No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chao-Yu Chen, MD, Assistant Professor, Obstetrics and Gynecology, Chang Gung Memorial Hospital, Chiayi, 6 West Sec, Chia-Pu Road, Puzi 613, Taiwan. b9002031@cgmh.org.tw
Received: May 12, 2022
Peer-review started: May 12, 2022
First decision: August 4, 2022
Revised: August 9, 2022
Accepted: October 17, 2022
Article in press: October 17, 2022
Published online: November 16, 2022
Core Tip

Core Tip: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) for peritoneal surface malignancy is associated with adverse effects which may affect quality of life (QoL). We aimed to investigate QoL after CRS/HIPEC, which has not previously been discussed in Taiwan. We prospectively enrolled patients from our center between 2018 and 2021. Our data showed that age and performance status were significantly correlated with QoL. In addition, QoL and symptom severity improved or returned to baseline in most categories within 3 mo after CRS/HIPEC. Our findings can help with preoperative consultation and perioperative care.