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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 16, 2022; 10(32): 11665-11670
Published online Nov 16, 2022. doi: 10.12998/wjcc.v10.i32.11665
Published online Nov 16, 2022. doi: 10.12998/wjcc.v10.i32.11665
Combined use of lactoferrin and vitamin D as a preventive and therapeutic supplement for SARS-CoV-2 infection: Current evidence
Massimiliano Cipriano, Department of Laparoscopic Surgery, Umberto I General Hospital, Medical School Sapienza University, Rome 161, Italy
Enzo Ruberti, Department of Human Neuroscience, Sapienza University of Rome, Rome 00185, Italy
Marcos Roberto Tovani-Palone, Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai 600 077, India
Author contributions: Cipriano M helped with study conception and design and writing of the manuscript; Ruberti E helped with study design and writing of the manuscript; Tovani-Palone MR helped with the writing of the original draft, and with critical review and editing of the manuscript.
Conflict-of-interest statement: All authors declare no conflicts of interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Marcos Roberto Tovani-Palone, PhD, Academic Research, Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai 600 077, India. marcos_palone@hotmail.com
Received: May 5, 2022
Peer-review started: May 5, 2022
First decision: June 16, 2022
Revised: July 10, 2022
Accepted: August 30, 2022
Article in press: August 30, 2022
Published online: November 16, 2022
Peer-review started: May 5, 2022
First decision: June 16, 2022
Revised: July 10, 2022
Accepted: August 30, 2022
Article in press: August 30, 2022
Published online: November 16, 2022
Core Tip
Core Tip: The combined use of lactoferrin, using a nasal spray formulation in association with its oral intake, and vitamin D could represent, through a synergistic action, a valuable therapy for coronavirus disease 2019 treatment and prevention.