Review
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 6, 2022; 10(31): 11226-11239
Published online Nov 6, 2022. doi: 10.12998/wjcc.v10.i31.11226
Endocrine disruptor chemicals as obesogen and diabetogen: Clinical and mechanistic evidence
Niyazi Emre Kurşunoğlu, Banu Pinar Sarer Yurekli
Niyazi Emre Kurşunoğlu, School of Medicine, Ege University, İzmir 35100, Turkey
Banu Pinar Sarer Yurekli, Department of Endocrinology, Ege University School of Medicine, İzmir 35100, Turkey
Author contributions: Kurşunoğlu EN searched the literature, prepared the figures, wrote the manuscript, and edited the manuscript; Yürekli BS searched the literature, and edited the manuscript.
Conflict-of-interest statement: The authors have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Banu Pinar Sarer Yurekli, MD, Associate Professor, Department of Endocrinology, Ege University School of Medicine, Ankara Street Bornova, İzmir 35100, Turkey. bsareryurekli@yahoo.com
Received: June 29, 2022
Peer-review started: June 29, 2022
First decision: August 1, 2022
Revised: August 19, 2022
Accepted: September 27, 2022
Article in press: September 27, 2022
Published online: November 6, 2022
Core Tip

Core Tip: An exogenous chemical, or mixture of chemicals, that interferes with any aspect of hormone action was defined as Endocrine-Disrupting Chemicals (EDCs). Obesogens can promote obesity by increasing the number of adipocytes and fat storage in existing adipocytes, changing the calories burned at rest, changing the energy balance, and finally regulating satiety. Besides the obesogenic effect, EDCs can cause type 2 diabetes mellitus through alteration in ß cell function and morphology and insulin resistance. In this review, we provide clinical and mechanistic evidence regarding EDCs as obesogen and diabetogen.