Meta-Analysis
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 14, 2022; 10(2): 585-593
Published online Jan 14, 2022. doi: 10.12998/wjcc.v10.i2.585
Efficacy and safety of argatroban in treatment of acute ischemic stroke: A meta-analysis
Bin Lv, Fang-Fang Guo, Jia-Cai Lin, Feng Jing
Bin Lv, Feng Jing, Department of Neurology, Chinese PLA General Hospital, Beijing 100853, China
Fang-Fang Guo, Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China
Jia-Cai Lin, Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya 572022, Hainan Province, China
Author contributions: Lv B and Guo FF contributed equally to this work; Lv B and Guo FF searched the related articles, analyzed the data, and wrote the manuscript; Lin JC analyzed and interpreted the data; Jing F conceived and designed this study, and made critical revision to the manuscript; all the authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors deny any conflict of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Feng Jing, MD, Doctor, Department of Neurology, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. jfsuccess@126.com
Received: June 18, 2021
Peer-review started: June 18, 2021
First decision: September 28, 2021
Revised: October 14, 2021
Accepted: December 2, 2021
Article in press: December 2, 2021
Published online: January 14, 2022
Core Tip

Core Tip: This study is the first meta-analysis that systematically assessed the efficacy and safety of argatroban as a cure for acute ischemic stroke (AIS). The results showed that argatroban might not benefit for AIS. Also, this meta-analysis further suggested that argatroban does not increase the risk of bleeding for AIS.