Copyright
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 6, 2022; 10(13): 4033-4041
Published online May 6, 2022. doi: 10.12998/wjcc.v10.i13.4033
Published online May 6, 2022. doi: 10.12998/wjcc.v10.i13.4033
Effect of calcium supplementation on severe hypocalcemia in patients with secondary hyperparathyroidism after total parathyroidectomy
Jun Liu, Meng Yang, Lin-Ping Huang, Department of General Surgery, China-Japan Friendship Hospital, Beijing 100029, China
Xue-Feng Fan, Department of General Surgery, Shougang General Hospital, Shougang 553000, Guizhou Province, China
Ling Zhang, Department of Nephrology, China-Japan Friendship Hospital, Beijing 100029, China
Author contributions: Liu J, Yang M, and Fan XF carried out the studies, collected data, and drafted the manuscript; Liu J and Yang M performed the statistical analysis and critically reviewed the manuscript for important intellectual content; Huang LP and Zhang L participated in the acquisition, analysis, or interpretation of data and drafted the manuscript; and all authors read and approved the final manuscript.
Supported by the Subject of Beijing Science and Technology Plan , No. Z191100006619014 .
Institutional review board statement: This work was carried out in accordance with the Declaration of Helsinki (2000) by the World Medical Association. The current retrospective study was approved by the institutional review board of China-Japan Friendship Hospital (2019-SDZL-12).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Meng Yang, MD, Doctor, Department of General Surgery, China-Japan Friendship Hospital, No. 2 East Yinghuayuan Street, Chaoyang District, Beijing 100029, China. hlpsurg406@sina.com
Received: March 31, 2021
Peer-review started: March 31, 2021
First decision: October 16, 2021
Revised: October 28, 2021
Accepted: April 9, 2022
Article in press: April 9, 2022
Published online: May 6, 2022
Peer-review started: March 31, 2021
First decision: October 16, 2021
Revised: October 28, 2021
Accepted: April 9, 2022
Article in press: April 9, 2022
Published online: May 6, 2022
Core Tip
Core Tip: Compared with conventional calcium supplementation (CS), preventive CS led to lower occurrence rates of hypocalcemia within 48 h and severe hypocalcemia (SH). Multivariable analysis showed that preoperative intact parathyroid hormone levels, preoperative alkaline phosphatase (ALP) amounts, preoperative serum phosphorus levels, and preventive CS were independently associated with SH. In patients with preoperative ALP > 500 U/L, only preventive CS was independently associated with SH.