Guo HJ, Jiang F, Chen C, Shi JY, Zhao YW. Plasma brain natriuretic peptide, platelet parameters, and cardiopulmonary function in chronic obstructive pulmonary disease. World J Clin Cases 2021; 9(36): 11165-11172 [PMID: 35071547 DOI: 10.12998/wjcc.v9.i36.11165]
Corresponding Author of This Article
Feng Jiang, MM, Attending Doctor, Department of Cardiology, Affiliated Hospital of Nantong University, No. 20 Xisi Road, Nantong 226001, Jiangsu Province, China. jiangfengjf53@163.com
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Case Control Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Hai-Jian Guo, Feng Jiang, Chu Chen, Jia-Yu Shi, Ya-Wen Zhao, Department of Cardiology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
Author contributions: Guo HJ and Chen C coordinated and conducted most of the experiments and data analysis and participated in drafting the manuscript; Zhao YW participated in data analysis; Shi JY performed data analysis and revised the manuscript; Jiang F supervised the project and experimental design and provided financial support; Guo HJ wrote the main part of the paper; and all authors read and approved the final manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of the Affiliated Hospital of Nantong University.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: No potential competing interests were reported by the authors.
Data sharing statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.
STROBE statement: The manuscript was checked according to the STROBE.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Feng Jiang, MM, Attending Doctor, Department of Cardiology, Affiliated Hospital of Nantong University, No. 20 Xisi Road, Nantong 226001, Jiangsu Province, China. jiangfengjf53@163.com
Received: September 14, 2021 Peer-review started: September 14, 2021 First decision: October 18, 2021 Revised: November 1, 2021 Accepted: November 18, 2021 Article in press: November 18, 2021 Published online: December 26, 2021
ARTICLE HIGHLIGHTS
Research background
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease with worldwide occurrence and high disability and mortality rate. Following the development of COPD, patients begin to show increased pulmonary circulation resistance, abnormal enhancement of vascular intima function, development of vascular fibrosis and occlusion, and remodeling of pulmonary circulation structure.
Research motivation
This study could serve as an important reference to explain the correlation of plasma brain natriuretic peptide (BNP) and platelet parameters with pulmonary arterial pressure and cardiac function classification in patients with COPD complicated with cor pulmonale.
Research objectives
This study aimed to investigate the correlation of plasma BNP and platelet parameters with cardiac function and pulmonary hypertension in patients with COPD and pulmonary heart disease.
Research methods
Fifty-two patients with COPD-pulmonary heart disease, 30 patients with COPD, and 30 healthy individuals were enrolled in the study. Plasma BNP and platelet count (PLT) parameters were estimated and compared among different groups and subgroups.
Research results
In the pulmonary heart disease, COPD, and control groups, the plasma BNP, platelet distribution width (PDW), and mean platelet volume (MPV) levels showed a decreasing trend, while the PLT and PCT levels showed an increasing trend. In patients with pulmonary heart disease, the plasma BNP, PDW, and MPV levels were positively correlated, and the PLT level was negatively correlated with their pulmonary artery pressure and cardiac function grade.
Research conclusions
Plasma BNP and PLT parameters are significantly correlated with cardiac function and pulmonary hypertension in patients with COPD and pulmonary heart disease, and these parameters can be used to monitor patients’ health status and recommend appropriate treatment.
Research perspectives
The mechanisms by which plasma BNP and platelet parameters affect pulmonary artery pressure and cardiac function should also be further studied.
