He J, Zhang YL, Wang LP, Liu XC. Impact of different stereoisomers of inositol on insulin sensitivity of gestational diabetes mellitus patients. World J Clin Cases 2021; 9(3): 565-572 [PMID: 33553394 DOI: 10.12998/wjcc.v9.i3.565]
Corresponding Author of This Article
Xiao-Chun Liu, MD, Associate Professor, Department of Obstetrics and Gynecology, Shanxi Bethune Hospital, Shanxi Medical University, No. 99 Longcheng Street, Taiyuan 030032, Shanxi Province, China. tyxchliu@163.com
Research Domain of This Article
Obstetrics & Gynecology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jan 26, 2021; 9(3): 565-572 Published online Jan 26, 2021. doi: 10.12998/wjcc.v9.i3.565
Impact of different stereoisomers of inositol on insulin sensitivity of gestational diabetes mellitus patients
Jing He, Yan-Li Zhang, Li-Ping Wang, Xiao-Chun Liu
Jing He, Yan-Li Zhang, Li-Ping Wang, Xiao-Chun Liu, Department of Obstetrics and Gynecology, Shanxi Bethune Hospital, Shanxi Medical University, Taiyuan 030032, Shanxi Province, China
Author contributions: He J and Zhang YL designed this study and wrote the article; Wang LP drafted the work and collected the data; Liu XC revised the paper for important intellectual content.
Institutional review board statement: The study was reviewed and approved by the Bethune Hospital of Shanxi Province Institutional Review Board [Approval No. YXLL-2020-062].
Conflict-of-interest statement: All authors declare no conflicts-of-interest related to this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xiao-Chun Liu, MD, Associate Professor, Department of Obstetrics and Gynecology, Shanxi Bethune Hospital, Shanxi Medical University, No. 99 Longcheng Street, Taiyuan 030032, Shanxi Province, China. tyxchliu@163.com
Received: October 27, 2020 Peer-review started: October 27, 2020 First decision: November 20, 2020 Revised: November 29, 2020 Accepted: December 6, 2020 Article in press: December 6, 2020 Published online: January 26, 2021
ARTICLE HIGHLIGHTS
Research background
Inositol has nine different isomers, of which the most representative of the human body are myoinositol (MI) and D-chiro-inositol (DCI).
Research motivation
The supplementation of inositol significantly improved insulin resistance in gestational diabetes mellitus (GDM) patients, and the effects of DCI on insulin resistance in GDM have not been reported.
Research objectives
Discuss the impact of different stereoisomers of inositol on insulin sensitivity of GDM patients.
Research methods
Eighty GDM pregnant women were divided into four groups according to their specified treatment regimen.
Research results
There was no statistical difference in the baseline data of each group. The levels of 2 h blood glucose, glycosylated hemoglobin, fasting insulin, total cholesterol, and triglyceride in the B, C, and D groups were significantly lower than those in the control group (A group) after treatment (P < 0.05).
Research conclusions
Treatment of different inositol stereoisomers (inositol MI and inositol DCI) can improve insulin sensitivity and reduce insulin resistance in diabetic patients. The inositol DCI was more effective in treating GDM than inositol MI.
