Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 6, 2021; 9(19): 5046-5053
Published online Jul 6, 2021. doi: 10.12998/wjcc.v9.i19.5046
Clinical and pathological features and risk factors for primary breast cancer patients
Ye-Yan Lei, Shuang Bai, Qing-Qing Chen, Xu-Jin Luo, Dong-Mei Li
Ye-Yan Lei, Shuang Bai, Qing-Qing Chen, Xu-Jin Luo, Dong-Mei Li, Department of Mammary Disease, Zhuhai Hospital of Guangdong Provincial Hospital of Traditional Chinese Medicine, Zhuhai 519015, Guangdong Province, China
Author contributions: Li DM designed this retrospective study; Li DM and Lei YY wrote this paper; Lei YY, Bai S, Chen QQ, and Luo XJ were responsible for sorting the data.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Guangdong Provincial Hospital of Traditional Chinese Medicine (No. ZE2020-286-01).
Conflict-of-interest statement: The authors have nothing to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dong-Mei Li, MM, Chief Physician, Department of Mammary Disease, Zhuhai Hospital of Guangdong Provincial Hospital of Traditional Chinese Medicine, No. 53 Jingle Road, Zhuhai 519015, Guangdong Province, China. 896184582@qq.com
Received: January 21, 2021
Peer-review started: January 21, 2021
First decision: March 11, 2021
Revised: March 23, 2021
Accepted: April 25, 2021
Article in press: April 25, 2021
Published online: July 6, 2021
ARTICLE HIGHLIGHTS
Research background

Breast cancer is the most common malignancy in women all around the world. According to the latest statistics in 2018, there were more than 2.08 million new breast cancer cases all around the world and more than 620000 deaths; the proportion of breast cancer deaths in women with cancer is 15%.

Research motivation

To retrospectively summarize and compare the disease history of patients with primary breast cancer and patients with benign thyroid tumors admitted to our hospital in the past 10 years to understand the clinicopathological characteristics and risk factors for primary breast cancer.

Research objectives

To investigate the clinical and pathological characteristics and risk factors for primary breast cancer and the Zhuhai to provide reference for prevention and screening of breast cancer.

Research methods

Through a retrospective case-control study, 149 patients with primary breast cancer diagnosed at the Department of Breast Medicine of Zhuhai Hospital of Guangdong Provincial Hospital of Traditional Chinese Medicine from January 2013 to March 2020 were included as a case group; they ranged in age from 26-95 years, with an average age of (48.20 ± 12.06) years. In addition, 165 patients with benign breast tumors admitted to Zhuhai Hospital of Guangdong Traditional Chinese Medicine Hospital from January 2019 to March 2020 were included as controls;, they ranged in age from 28-69 years, with an average age of (42.36 ± 7.7) years. SPSS22.0 statistical software was used for statistical analyses.

Research results

Invasive ductal cancer was the main type of invasive carcinoma. Breast cancer patients with stage I/II disease accounted for 69.2% of all cases. Luminal B was the most common molecular type, accounting for 62.4% of cases, of which 36.2% were HER2 negative and 26.2% were positive.

Research conclusions

This study found that distant metastasis at first diagnosis is more common among elderly women aged ≥ 60 years, that advanced age, late menarche, and late childbearing age are risk factors for the onset of primary breast cancer, and that a surgical history of benign breast lesions is the primary protective factor against breast cancer.

Research perspectives

Further studies with large multicenter samples are needed.