Published online Jul 6, 2021. doi: 10.12998/wjcc.v9.i19.5046
Peer-review started: January 21, 2021
First decision: March 11, 2021
Revised: March 23, 2021
Accepted: April 25, 2021
Article in press: April 25, 2021
Published online: July 6, 2021
Breast cancer is the most common malignancy in women all around the world. According to the latest statistics in 2018, there were more than 2.08 million new breast cancer cases all around the world and more than 620000 deaths; the proportion of breast cancer deaths in women with cancer is 15%.
To retrospectively summarize and compare the disease history of patients with primary breast cancer and patients with benign thyroid tumors admitted to our hospital in the past 10 years to understand the clinicopathological characteristics and risk factors for primary breast cancer.
To investigate the clinical and pathological characteristics and risk factors for primary breast cancer and the Zhuhai to provide reference for prevention and screening of breast cancer.
Through a retrospective case-control study, 149 patients with primary breast cancer diagnosed at the Department of Breast Medicine of Zhuhai Hospital of Guangdong Provincial Hospital of Traditional Chinese Medicine from January 2013 to March 2020 were included as a case group; they ranged in age from 26-95 years, with an average age of (48.20 ± 12.06) years. In addition, 165 patients with benign breast tumors admitted to Zhuhai Hospital of Guangdong Traditional Chinese Medicine Hospital from January 2019 to March 2020 were included as controls;, they ranged in age from 28-69 years, with an average age of (42.36 ± 7.7) years. SPSS22.0 statistical software was used for statistical analyses.
Invasive ductal cancer was the main type of invasive carcinoma. Breast cancer patients with stage I/II disease accounted for 69.2% of all cases. Luminal B was the most common molecular type, accounting for 62.4% of cases, of which 36.2% were HER2 negative and 26.2% were positive.
This study found that distant metastasis at first diagnosis is more common among elderly women aged ≥ 60 years, that advanced age, late menarche, and late childbearing age are risk factors for the onset of primary breast cancer, and that a surgical history of benign breast lesions is the primary protective factor against breast cancer.
Further studies with large multicenter samples are needed.