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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Clinicopathological characteristics and prognosis of gastric signet ring cell carcinoma
Hua-Kai Tian, Zuo Zhang, Zhi-Kun Ning, Jiang Liu, Zi-Tao Liu, Hao-Yu Huang, Zhen Zong, Hui Li
Hua-Kai Tian, Department of General Surgery, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Zuo Zhang, Department of Obstetrics and Gynecology, Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Zhi-Kun Ning, Department of Day Ward, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Jiang Liu, Zi-Tao Liu, Hao-Yu Huang, Zhen Zong, Department of Gastrointestinal Surgery, Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Hui Li, Department of Rheumatology and Immunology, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Author contributions: Tian HK, Zhang Z, and Ning ZK contributed equally to this work; Tian HK and Li H conceived and designed this study; Zhang Z and Ning ZK collected and assembled the data; Zhang Z and Liu J analysed and interpreted the data; Tian HK and Liu J drafted the manuscript; Zong Z, Liu ZT, and Huang HY prepared the figures and tables; all authors read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 81860433; Natural Science Youth Foundation of Jiangxi Province, No. 20192BAB215036; Jiangxi Province Natural Science Key R&D Project-General Project, No. 20202BBG73024; Training Plan for Academic and Technical Young Leaders of Major Disciplines in Jiangxi Province, No. 20204BCJ23021; and Jiangxi Provincial Education Department, Science and Technology Research Project-Youth Project, No. GJJ210252.
Institutional review board statement: The Ethics Committee of the Second Affiliated Hospital of Nanchang University approved the study [No. Review[
2018]No.(100)].
Informed consent statement: Since this is a retrospective clinical study, no informed consent form was signed.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Hui Li, MD, Doctor, Department of Rheumatology and Immunology, First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Donghu District, Nanchang 330006, Jiangxi Province, China. lihui0791nc@126.com
Received: May 22, 2022
Peer-review started: May 22, 2022
First decision: July 14, 2022
Revised: July 21, 2022
Accepted: September 1, 2022
Article in press: September 1, 2022
Published online: October 16, 2022
ARTICLE HIGHLIGHTS
Research background
The clinicopathological features and prognosis of gastric signet ring cell carcinoma (GSRC) remain controversial, particularly with regard to sensitivity to postoperative adjuvant therapy.
Research motivation
To our knowledge, this study is the first to analyse and compare the clinicopathological features and prognosis of GSRC with gastric adenocarcinoma of different degrees of differentiation and includes both Eastern and Western populations.
Research objectives
The aim of this study was to compare the pathological features of GSRC with those of gastric adenocarcinoma of different degrees of differentiation and the differences in survival prognosis between the different disease processes.
Research methods
This study was first conducted by analysing the differences in clinicopathological features between GSRC and gastric adenocarcinoma in Western populations and comparing the survival prognosis of the different processes. Finally, validation was performed using an Eastern population.
Research results
GSRC was more commonly seen in younger female patients and was more aggressive in the progressive stage, showing more common lymph node metastasis and larger tumour size. However, the prognosis of early GSRC was relatively good, even better than that of differentiated adenocarcinoma. The prognosis of advanced GSRC was not significantly different from that of undifferentiated gastric adenocarcinoma and was worse than that of differentiated gastric adenocarcinoma. Postoperative adjuvant radiotherapy can improve the survival rate of GPC.
Research conclusions
The prognosis of GSRC is better than that of undifferentiated type, especially in EGC, and its prognosis is even better than that of differentiated type. GSRC patients can benefit from early detection, surgical resection, and aggressive adjuvant therapy.
Research perspectives
GSRC has unique clinicopathological features and prognosis, and early diagnosis and treatment can significantly improve survival rates. Patients may benefit from postoperative adjuvant radiotherapy, but further validation is needed.
