Li XJ, Yang L, Yan XF, Zhan CT, Liu JH. Granulomatosis with polyangiitis presenting as high fever with diffuse alveolar hemorrhage and otitis media: A case report. World J Clin Cases 2021; 9(10): 2344-2351 [PMID: 33869612 DOI: 10.12998/wjcc.v9.i10.2344]
Corresponding Author of This Article
Jiang-Hua Liu, MD, Doctor, Department of General Practice, The Second Affiliated Hospital of Guangxi Medical University, No. 166 East University Road, Nanning 530007, Guangxi Zhuang Autonomous Region, China. jianghualiu0107@163.com
Research Domain of This Article
Otorhinolaryngology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Apr 6, 2021; 9(10): 2344-2351 Published online Apr 6, 2021. doi: 10.12998/wjcc.v9.i10.2344
Granulomatosis with polyangiitis presenting as high fever with diffuse alveolar hemorrhage and otitis media: A case report
Xiao-Jie Li, Liu Yang, Xiao-Feng Yan, Chu-Ting Zhan, Jiang-Hua Liu
Xiao-Jie Li, Liu Yang, Xiao-Feng Yan, Chu-Ting Zhan, Jiang-Hua Liu, Department of General Practice, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, Guangxi Zhuang Autonomous Region, China
Jiang-Hua Liu, Department of General Practice, General Practice School of Guangxi Medical University, Nanning 530007, Guangxi Zhuang Autonomous Region, China
Author contributions: Liu JH and Yang L conducted the studies, participated in collecting the data, and drafted the manuscript; Yan XF and Zhan CT participated in the study design and performed the statistical analyses; Liu JH and Li XJ participated in the acquisition, analysis, or interpretation of data and drafted the manuscript; All authors read and approved the final manuscript.
Informed consent statement: Inform written consent was obtained from the patient for publication of this report and accompanying images.
Conflict-of-interest statement: All authors have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jiang-Hua Liu, MD, Doctor, Department of General Practice, The Second Affiliated Hospital of Guangxi Medical University, No. 166 East University Road, Nanning 530007, Guangxi Zhuang Autonomous Region, China. jianghualiu0107@163.com
Received: October 27, 2020 Peer-review started: October 27, 2020 First decision: November 20, 2020 Revised: December 3, 2020 Accepted: February 11, 2021 Article in press: February 11, 2021 Published online: April 6, 2021
Abstract
BACKGROUND
Granulomatosis with polyangiitis is a necrotizing inflammation of small and medium-sized vessels accompanied by formation of granuloma, involvement of primary granulomatous upper and lower respiratory tracts, glomerulonephritis, and vasculitis of small vessels.
CASE SUMMARY
Herein, we described a case of a 52-year-old man admitted with pulmonary nodules and high fever. Autoantibody workup revealed that the patient was positive for c-anti-neutrophil cytoplasmic antibodies and proteinase-3 anti-neutrophil cytoplasmic antibodies. Pulmonary biopsies revealed a local granulomatous structure. The patient received therapy with methylprednisolone and intravenous immunoglobulin, and his clinical symptoms improved.
CONCLUSION
Intravenous immunoglobulin may act on granulomatosis with polyangiitis similar to immunosuppressants.
Core Tip: By reviewing a patient diagnosed with granulomatosis with polyangiitis, we found that intravenous immunoglobin combined with methylprednisolone can reduce the symptoms of pulmonary hemorrhage. These findings differ from previous reports, and provide more possibilities for the treatment of similar conditions.
