Published online Jul 6, 2019. doi: 10.12998/wjcc.v7.i13.1696
Peer-review started: March 25, 2019
First decision: April 11, 2019
Revised: April 29, 2019
Accepted: May 10, 2019
Article in press: May 11, 2019
Published online: July 6, 2019
Gastric adenocarcinoma of fundic gland type (GA-FG) has recently been proposed as a novel histological type of gastric cancer.
We report a case of GA-FG in a 77-year-old Chinese woman with epigastric distention who was referred to endoscopy for the management of an incidentally found submucosal tumor-like elevated lesion in the lower part of the gastric body. The tumor occurred after Helicobacter pylori (H. pylori) eradication therapy without long-term use of proton pump inhibitors. Complete and curable removal of the tumor was performed by endoscopic submucosal dissection. Histopathological findings showed numerous cells with basophilic cytoplasm and mildly atypical nuclei-like chief cells of the fundic gland. The tumor was observed to have the so-called “endless glands” pattern of the well-differentiated mixed phenotype. A safe resection margin without lymphatic and venous invasion was observed. As the tumor occurred after H. pylori eradication therapy, it is unknown whether there was a relationship with H. pylori eradication. The patient will be followed up by periodic gastroscopic observation.
In conclusion, we report a case of GA-FG after H. pylori eradication therapy without long-term proton pump inhibitors use. Further analysis of similar cases will reveal the clinical behavior of GA-FG.
Core tip: Gastric adenocarcinoma of fundic gland type (GA-FG) remains a rare disease despite a recent uptick in diagnoses. Here, we report a case of GA-FG with submucosal tumor-like appearance, located in the lower part of the gastric body. This case report discusses the probability-of-occurrence after Helicobacter pylori eradication therapy without long-term usage of proton pump inhibitors. Complete and curable removal of endoscopic submucosal dissection was performed. Further analysis of similar cases will reveal the clinical behavior of GA-FG.