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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Effect of Helicobacter pylori eradication on elder cases: Observational study in community-based medicine
Masaki Maruyama, Kenya Kamimura, Ayako Hoshiyama, Koki Hoshiyama, Mari Hoshiyama, Yoshihiro Hoshiyama, Shuji Terai
Masaki Maruyama, Department of Gastroenterology, Kashiwazaki General Hospital and Medical Center, Kashiwazaki, Niigata 945-8535, Japan
Masaki Maruyama, Ayako Hoshiyama, Koki Hoshiyama, Mari Hoshiyama, Department of Internal Medicine, Kashiwazaki Chuo Hospital, Kashiwazaki, Niigata 945-0055, Japan
Kenya Kamimura, Shuji Terai, Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Chuo-Ku, Niigata 951-8510, Japan
Yoshihiro Hoshiyama, Department of Surgery, Kashiwazaki Chuo Hospital, Kashiwazaki, Niigata 945-0055, Japan
Author contributions: All authors contributed to this manuscript.
Institutional review board statement: This study was reviewed and approved by the institutional review board of Kashiwazaki Central Hospital.
Informed consent statement: Written informed consents were obtained from the patients to present their information.
Conflict-of-interest statement: The authors declare that they have no current financial arrangement or affiliation with any organization that may have a direct influence on their work.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Kenya Kamimura, MD, PhD, Assistant Professor, Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachido-ri, Chuo-ku, Niigata 951-8510, Japan. kenya-k@med.niigata-u.ac.jp
Telephone: +81-25-2272207 Fax: +81-25-2270776
Received: August 4, 2017
Peer-review started: August 8, 2017
First decision: September 20, 2017
Revised: September 27, 2017
Accepted: October 29, 2017
Article in press: October 29, 2017
Published online: December 16, 2017
AIM
To examine the effect of Helicobacter pylori (H. pylori) eradication therapy on the extra-gastrointestinal factors in elderly patients by a before-after observational study in community medicine.
METHODS
Medical records (1 May 2013-31 January 2014) of 130 patients who underwent H. pylori eradication therapy with 2-year after-eradication observation in our institute were reviewed. Data on sex; age; body weight; body mass index (BMI); mean corpuscular volume (MCV); total protein; low-density lipoprotein cholesterol, triglyceride, haemoglobin A1c and haemoglobin levels and gastric hyperplastic polyps (GHPs) at eradication was extracted. Two-year after-eradication change in data was analysed by paired-sample t-test; relationship between GHPs and subclinical iron deficiency anaemia (IDA) improvement was evaluated.
RESULTS
The mean patient age (median, interquartile range) at eradication was 69.6 (71.5, 64-77) years. Paired-sample t-tests showed that body weight, BMI and MCV increased by 0.52 kg (P = 0.018), 0.25 kg/m2 (P = 0.006) and 0.83 fL (P < 0.001), respectively. The nonparametric Mann-Whitney test showed no significant difference in the change rate of MCV after eradication between the groups with and without GHPs (P = 0.892).
CONCLUSION
H. pylori eradication therapy prevented weight loss and subclinical IDA in elderly individuals. GHPs were not associated with subclinical IDA.
Core tip: The effect of Helicobacter pylori (H. pylori) eradication therapy on the extra-gastrointestinal factors in elderly patients was focused in this study. H. pylori eradication therapy prevented weight loss and subclinical iron deficiency anaemia (IDA) in elderly individuals. Gastric hyperplastic polyps were not associated with subclinical IDA. The results obtained in this study will help physician to treat elderly patients in community-based medicine.
