Published online Apr 16, 2014. doi: 10.12998/wjcc.v2.i4.111
Revised: March 2, 2014
Accepted: March 13, 2014
Published online: April 16, 2014
Reactive nodular fibrous pseudotumor (RNFP), which presents abdominal clinical manifestations and malignant radiographic results, usually requires radical resection as the treatment. However, RNFP has been recently described as an extremely rare benign post-inflammatory lesion of a reactive nature, which typically arises from the sub-serosal layer of the digestive tract or within the surrounding mesentery in association with local injury or inflammation. In addition, a postoperative diagnosis is necessary to differentiate it from the other reactive processes of the abdomen. Furthermore, RNFP shows a good prognosis without signs of recurrence or metastasis. A 16-year-old girl presented with a 3-mo history of epigastric discomfort, and auxiliary examinations suggested a malignant tumor originating from the stomach; postoperative pathology confirmed RNFP, and after a 2-year follow-up period, the patient did not display any signs of recurrence. This case highlights the importance of preoperative pathology for surgeons who may encounter similar cases.
Core tip: Our case report describes a rare benign tumor originating from the gastrointestinal tract. To date, this lesion has been reported in 20 cases worldwide. The most significant and important insights are that these diseases possess fairly good prognosis with opposite radiographic and clinical findings. Pathologically, reactive nodular fibrous pseudotumor (RNFP) was recently described arising from the sub-serosal layer or within the surrounding mesentery. However, the veracity of the pathological examination results and the etiology are still controversial. We will describe the complete diagnostic and therapeutic process of a young girl with RNFP and will retrospectively analyze the previously reported cases, particularly the microscopic and immunohistochemical characteristics.