Wang YJ, Fan DM, Xu YS, Zhao Q, Li ZF. Clinical experience sharing on gastric microneuroendocrine tumors: A case report. World J Clin Cases 2024; 12(4): 795-800 [PMID: 38322680 DOI: 10.12998/wjcc.v12.i4.795]
Corresponding Author of This Article
Zhen-Fang Li, MM, Chief Physician, Doctor, Department of Gastroenterology, Central Hospital Affiliated to Shandong First Medical University, No. 105 Jiefang Road, Jinan 250000, Shandong Province, China. klyjr@sina.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Feb 6, 2024; 12(4): 795-800 Published online Feb 6, 2024. doi: 10.12998/wjcc.v12.i4.795
Clinical experience sharing on gastric microneuroendocrine tumors: A case report
You-Jun Wang, Da-Ming Fan, Yu-Shuang Xu, Qi Zhao, Zhen-Fang Li
You-Jun Wang, Qi Zhao, Zhen-Fang Li, Department of Gastroenterology, Central Hospital Affiliated to Shandong First Medical University, Jinan 250000, Shandong Province, China
Da-Ming Fan, Department of Pathology, Central Hospital Affiliated to Shandong First Medical University, Jinan 250000, Shandong Province, China
Yu-Shuang Xu, Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, China
Author contributions: Wang YJ contributed to manuscript writing and editing, and data collection; Fan DM and Xu YS contributed to data analysis; Zhao Q and Li ZF contributed to conceptualization and supervision; and all authors contributed to writing of the manuscript.
Informed consent statement: Informed written consent was obtained from the patients for the publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhen-Fang Li, MM, Chief Physician, Doctor, Department of Gastroenterology, Central Hospital Affiliated to Shandong First Medical University, No. 105 Jiefang Road, Jinan 250000, Shandong Province, China. klyjr@sina.com
Received: September 27, 2023 Peer-review started: September 27, 2023 First decision: December 7, 2023 Revised: December 14, 2023 Accepted: January 10, 2024 Article in press: January 10, 2024 Published online: February 6, 2024
Abstract
BACKGROUND
The majority of gastric neuroendocrine tumors (G-NENs) are present in various lesions under endoscopy, and they can be polypoid uplifts, submucosal tumors or papules, erosions, and ulcers. The lesions are mostly confined to the mucosal or submucosal layer, usually less than 2 cm, and exclusively localized to the gastric body or fundus. In type 1 G-NENs, about 22% of cases have no visible lesions under an endoscope, and such lesions can only be detected via biopsies (microcarcinoids).
CASE SUMMARY
A 67-year-old female patient with appetite loss for more than half a year and personal history of hyperthyroidism was admitted to our hospital. After admission, a random multi-point biopsy was performed on the gastric body, fundus, angle, and antrum through gastroscopy. Pathological examination showed chronic severe atrophic gastritis in the fundus and body of the stomach. The small curvature of the gastric body, the anterior wall of the gastric body, and the posterior wall of the gastric body displayed proliferation of intestinal chromaffin cells. The curvature of the gastric body showed neuroendocrine tumor G1 (carcinoid), while the antrum and angle of the stomach showed mild atrophic gastritis with mild intestinal metaplasia. Immunohistochemical examination showed that the greater curvature of the gastric body was Syn (+), CgA (+), and Ki-67 (+, approximately 1%), which is consistent with neuroendocrine tumors (grade 1). Regular gastroscopy and biopsy should be performed every one to two years to monitor G-NENs.
CONCLUSION
In the case under study, the patient did not have any visible raised lesions under a gastroscope, and the lesions were found only after a random biopsy. This article combines the endoscopic manifestations and clinical features of the lesions in this case to improve the diagnosis of G-NENs.
Core Tip: Gastric neuroendocrine tumor (G-NEN) is a group of rare tumors originating from neuroendocrine cells in the stomach. Especially in type 1 G-NEN, some cases have no visible lesions under endoscopy, and these lesions can only be detected via biopsies (microcarcinoids). Therefore, it is particularly important to correctly identify and diagnose diseases. This article reports a case of a 67-year-old female patient with gastric microneuroendocrine tumors, and reviews relevant literature to better identify and diagnose gastric microneuroendocrine tumors.
