Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 6, 2024; 12(13): 2194-2200
Published online May 6, 2024. doi: 10.12998/wjcc.v12.i13.2194
Therapeutic effect of Wendan Decoction combined with mosapride on gastroesophageal reflux disease after esophageal cancer surgery
Yu-Jing Zhang, Shen-Ping Wu
Yu-Jing Zhang, Shen-Ping Wu, Department of Oncology, Beijing Integrated Traditional Chinese and Western Medicine Hospital, Beijing 100039, China
Author contributions: Zhang YJ and Wu SP proposed the concept of this study; Wu SP participated in the data collection; Zhang YJ and Wu SP wrote the initial draft; Wu SP contributed to the formal analysis; Zhang YJ conducted guiding research, methodology, and visualization of the manuscript; Both authors participated in this study, validated it, and jointly reviewed and edited the manuscript.
Institutional review board statement: This study has been reviewed and approved by the Ethics Committee of Beijing Integrated Traditional Chinese and Western Medicine Hospital
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: We declare that there is no disclosure of any conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu-Jing Zhang, MM, Attending Doctor, Department of Oncology, Beijing Integrated Traditional Chinese and Western Medicine Hospital, No. 3 East Street, Yongding Road, Haidian District, Beijing 100039, China. tzvz674@163.com
Received: January 25, 2024
Peer-review started: January 25, 2024
First decision: February 8, 2024
Revised: February 9, 2024
Accepted: March 27, 2024
Article in press: March 27, 2024
Published online: May 6, 2024
Abstract
BACKGROUND

Gastroesophageal reflux disease (GERD) is a common complication of esophageal cancer surgery that can affect quality of life and increase the risk of esophageal stricture and anastomotic leakage. Wendan Decoction (WDD) is a traditional Chinese herbal formula used to treat various gastrointestinal disorders, such as gastritis, functional dyspepsia, and irritable bowel syndrome. Mosapride, a prokinetic agent, functions as a selective 5-hydroxytryptamine 4 agonist, enhancing gastrointestinal motility.

AIM

To evaluate the therapeutic effects of WDD combined with mosapride on GERD after esophageal cancer surgery.

METHODS

Eighty patients with GERD were randomly divided into treatment (receiving WDD combined with mosapride) and control (receiving mosapride alone) groups. The treatment was conducted from January 2021 to January 2023. The primary outcome was improved GERD symptoms as measured using the reflux disease questionnaire (RDQ). The secondary outcomes were improved esophageal motility (measured using esophageal manometry), gastric emptying (measured using gastric scintigraphy), and quality of life [measured via the Short Form-36 (SF-36) Health Survey].

RESULTS

The treatment group showed a notably reduced RDQ score and improved esophageal motility parameters, such as lower esophageal sphincter pressure, peristaltic amplitude, and peristaltic velocity compared to the control group. The treatment group showed significantly higher gastric emptying rates and SF-36 scores (in both physical and mental domains) compared to the control group. No serious adverse effects were observed in either group.

CONCLUSION

WDD combined with mosapride is an effective and safe therapy for GERD after esophageal cancer surgery. It can improve GERD symptoms, esophageal motility, gastric emptying, and the quality of life of patients. Further studies with larger sample sizes and longer follow-up periods are required to confirm these findings.

Keywords: Gastroesophageal reflux disease, Esophageal cancer surgery, Wendan Decoction, Mosapride, Treatment effects, Gastroesophageal reflux disease symptoms

Core Tip: This study suggests that combining Wendan Decoction with mosapride is an effective and safe therapy for managing gastroesophageal reflux disease (GERD) after esophageal cancer surgery. It improves GERD symptoms, esophageal motility, gastric emptying, and the quality of life of patients. Larger studies with longer follow-up periods are needed to further validate these findings.