Published online Mar 26, 2023. doi: 10.12998/wjcc.v11.i9.2119
Peer-review started: December 20, 2022
First decision: January 30, 2023
Revised: January 30, 2023
Accepted: March 1, 2023
Article in press: March 1, 2023
Published online: March 26, 2023
The vagina has diverse vaginal microbes (Vm). A disturbance in the delicate balance maintained in Vm is linked to women's obstetrical and reproductive tract problems. Vaginal microbes play an essential role in protecting the health of the female reproductive tract by alleviating gynecological infection. However, Vm profiling has many confounders that need to be addressed during sampling, including age, race, pregnancy, medical illness, and smoking. Vm profiling improves reproduction odds, may serve as a marker for genital malignancies and have a therapeutic application in menopausal women and women with cervical cancers.
Core Tip: The vaginal ecosystem has a key role in women's health. Vaginal microbes (Vm) affect the obstetrical performance of pregnant women and, in turn, can be affected by age, gestational age, race, and time of sampling. For infertile women, Vm composition can affect fertilization odds, the success of assisted reproduction technique, and even may predict the chances of live birth. The therapeutic aspect of Vm was introduced to enhance vaginal protection against infection, alleviate menopausal symptoms, and, finally, in genital malignancies. Vm was used as a signature marker in predicting and preventing ovarian and cervical malignancies, respectively.