Xu ZH, Ma MH, Li YQ, Li LL, Liu GH. Progress and expectation of stem cell therapy for diabetic wound healing. World J Clin Cases 2023; 11(3): 506-513 [PMID: 36793646 DOI: 10.12998/wjcc.v11.i3.506]
Corresponding Author of This Article
Gui-Hua Liu, MD, PhD, Associate Chief Physician, Associate Research Scientist, Reproductive Medicine Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Yuancuner Road, Tianhe District, Guangzhou 510610, Guangdong Province, China. liuguihua@mail.sysu.edu.cn
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jan 26, 2023; 11(3): 506-513 Published online Jan 26, 2023. doi: 10.12998/wjcc.v11.i3.506
Progress and expectation of stem cell therapy for diabetic wound healing
Zhen-Han Xu, Meng-Hui Ma, Yan-Qing Li, Li-Lin Li, Gui-Hua Liu
Zhen-Han Xu, Meng-Hui Ma, Yan-Qing Li, Li-Lin Li, Gui-Hua Liu, Reproductive Medicine Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510610, Guangdong Province, China
Author contributions: Xu ZH, Ma MH, Li YQ, Li LL and Liu GH designed the research study; Xu ZH, Ma MH, Li YQ and Li LL performed the research; Xu ZH and Ma MH contributed literature search; Xu ZH, Li LL and Liu GH contributed data analysis; Xu ZH and Li YQ wrote the manuscript; All authors have read and approve the final manuscript.
Supported byThe National Natural Science Foundation of China, No. 82171604.
Conflict-of-interest statement: All the authors declare that there are no conflicts of interest associated with this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gui-Hua Liu, MD, PhD, Associate Chief Physician, Associate Research Scientist, Reproductive Medicine Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Yuancuner Road, Tianhe District, Guangzhou 510610, Guangdong Province, China. liuguihua@mail.sysu.edu.cn
Received: August 31, 2022 Peer-review started: August 31, 2022 First decision: September 26, 2022 Revised: November 8, 2022 Accepted: January 9, 2023 Article in press: January 9, 2023 Published online: January 26, 2023
Abstract
Impaired wound healing presents great health risks to diabetics. Encouragingly, the current clinical successfully found out meaningful method to repair wound tissue, and stem cell therapy could be an effective method for diabetic wound healing with its ability to accelerate wound closure and avoid amputation. This minireview aims at introducing stem cell therapy for facilitating tissue repair in diabetic wounds, discussing the possible therapeutic mechanism and clinical application status and problems.
Core Tip: Diabetic wound is a common complication of diabetes and stem cell therapy is an effective treatment for diabetic wounds. It helps improve wounds mainly by regulating inflammation and blood circulation. At present, many kinds of stem cells have been used and studied, and good results have been achieved. However, there are still problems that need to be solved. Here we discuss the current role and progress of stem cells in the treatment of diabetic wounds.
