Published online Jul 16, 2023. doi: 10.12998/wjcc.v11.i20.4788
Peer-review started: March 20, 2023
First decision: April 11, 2023
Revised: April 24, 2023
Accepted: June 13, 2023
Article in press: June 13, 2023
Published online: July 16, 2023
Breast cancer (BC) remains a public health problem. Tamoxifen (TAM) resistance has caused great difficulties for treatment of BC patients. Eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1) plays critical roles in the tumorigenesis and progression of BC. However, the expression and mechanism of EIF4EBP1 in determining the efficacy of TAM therapy in BC patients are still unclear.
To investigate the expression and functions of EIF4EBP1 in determining the efficacy of TAM therapy in BC patients.
High-throughput sequencing data of breast tumors were downloaded from the Gene Expression Omnibus database. Differential gene expression analysis identified EIF4EBP1 to be significantly upregulated in cancer tissues. Its prognostic value was analyzed. The biological function and related pathways of EIF4EBP1 was analyzed. Subsequently, the expression of EIF4EBP1 was deter
EIF4EBP1 was upregulated in the TAM-resistant cells, and EIF4EBP1 was related to the prognosis of BC patients. Gene Set Enrichment Analysis showed that EIF4EBP1 might be involved in Hedgehog signaling pathways. Decreasing the expression of EIF4EBP1 could reverse TAM resistance, whereas overexpression of EIF4EBP1 promoted TAM resistance.
This study indicated that EIF4EBP1 was overexpressed in the BC and TAM-resistant cell line, which increased cell proliferation, invasion, migration and TAM resistance in BC cells.
Core Tip: Breast cancer is the most frequently diagnosed cancer in women and the leading cause of female deaths from cancer worldwide. Eukaryotic translation initiation factor 4E binding protein 1 was overexpressed in the breast cancer tamoxifen-resistant cell line, and high expression of eukaryotic translation initiation factor 4E binding protein 1 was associated with poor prognosis in tamoxifen-treated patients.