Song JS, Hong KT, Song KJ, Kim SJ. Repair of a large patellar cartilage defect using human umbilical cord blood-derived mesenchymal stem cells: A case report. World J Clin Cases 2022; 10(34): 12665-12670 [PMID: 36579106 DOI: 10.12998/wjcc.v10.i34.12665]
Corresponding Author of This Article
Seok Jung Kim, FRCS, MD, PhD, Director, Full Professor, Department of Orthopedic Surgery, Uijeongbu Street Mary’s Hospital, College of Medicine, The Catholic University of Korea, No. 271 Cheonbo-ro, Uijeongbu 11765, Gyeonggi-do, South Korea. peter@catholic.ac.kr
Research Domain of This Article
Orthopedics
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Dec 6, 2022; 10(34): 12665-12670 Published online Dec 6, 2022. doi: 10.12998/wjcc.v10.i34.12665
Repair of a large patellar cartilage defect using human umbilical cord blood-derived mesenchymal stem cells: A case report
Jun-Seob Song, Ki-Taek Hong, Ki Jeon Song, Seok Jung Kim
Jun-Seob Song, Ki-Taek Hong, Department of Orthopedic Surgery, Gangnam JS Hospital, Seoul 06053, South Korea
Ki Jeon Song, Seok Jung Kim, Department of Orthopedic Surgery, Uijeongbu Street Mary’s Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu 11765, Gyeonggi-do, South Korea
Author contributions: Song JS and Song KJ conceived the study and wrote the manuscript; Hong KT participated in its design and coordination and helped to draft the manuscript; Kim SJ analyzed data; All authors read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient’s parents.
Conflict-of-interest statement: All authors report no relevant conflict of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Seok Jung Kim, FRCS, MD, PhD, Director, Full Professor, Department of Orthopedic Surgery, Uijeongbu Street Mary’s Hospital, College of Medicine, The Catholic University of Korea, No. 271 Cheonbo-ro, Uijeongbu 11765, Gyeonggi-do, South Korea. peter@catholic.ac.kr
Received: July 10, 2022 Peer-review started: July 10, 2022 First decision: August 22, 2022 Revised: September 10, 2022 Accepted: November 2, 2022 Article in press: November 2, 2022 Published online: December 6, 2022
Abstract
BACKGROUND
Patellar dislocation may cause cartilage defects of various sizes. Large defects commonly require surgical treatment; however, conventional treatments are problematic.
CASE SUMMARY
A 15-year-old male with a large patellar cartilage defect due to patellar dislocation was treated via human umbilical cord blood-derived mesenchymal stem cell (hUCB-MSC) implantation. To our knowledge, this is the first report of this treatment for this purpose. The patient recovered well as indicated by good visual analog scale, International Knee Documentation Committee and McMaster Universities Osteoarthritis Index scores. Magnetic resonance imaging showed cartilage regeneration 18 mo postoperatively.
CONCLUSION
Umbilical cord blood-derived hUCB-MSCs may be a useful treatment option for the repair of large patellar cartilage defects.
Core Tip: Umbilical cord blood-derived mesenchymal stem cells consist of a unique population of progenitors co-expressing mesenchymal stem cells and neuronal markers capable of instantaneous differentiation. This report is of a 15-year-old male teen with a large patellar cartilage defect due to patellar dislocation who was treated with implantation of human umbilical cord blood-derived mesenchymal stem cells.
