Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 26, 2022; 10(33): 12422-12429
Published online Nov 26, 2022. doi: 10.12998/wjcc.v10.i33.12422
Danggui Sini decoction treatment of refractory allergic cutaneous vasculitis: A case report
Xi-Ya Chen, Zhi-Ming Wu, Rui Wang, Yu-Hong Cao, Yong-Lian Tao
Xi-Ya Chen, Yu-Hong Cao, Yong-Lian Tao, The Second Clinical Medical College, Yunnan University of Chinese Traditional Medicine, Kunming 650000, Yunnan Province, China
Zhi-Ming Wu, School of Basic Medicine, Yunnan University of Chinese Traditional Medicine, Kunming 650000, Yunnan Province, China
Rui Wang, First Affiliated Hospital, Kunming Medical University, Kunming 650000, Yunnan Province, China
Author contributions: Chen XY, Wang R, Cao YH, and Tao YL collected the data and drafted the manuscript; Wu ZM conceived of the study, and participated in the designing, writing, reviewing, and revising of this manuscript; all authors contributed to the article and approved the submitted version.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Zhi-Ming Wu, PhD, Professor, School of Basic Medicine, Yunnan University of Chinese Traditional Medicine, No. 1076 Yuhua Street, Chenggong District, Kunming 650000, Yunnan Province, China.
Received: September 5, 2022
Peer-review started: September 5, 2022
First decision: September 26, 2022
Revised: October 5, 2022
Accepted: October 31, 2022
Article in press: October 31, 2022
Published online: November 26, 2022

Allergic cutaneous vasculitis (ACV) is a difficult disease to treat. At present, there is no effective treatment for this condition. Traditionally, immunosuppressants and hormones have been primarily used in its management, but the treatment effect is suboptimal, and it has several side effects.


We present the case of a 19-year-old woman who presented at our hospital with a four-year history of symmetric skin lesions mainly affecting her lower extremities. She had previously undergone treatment with prednisolone acetate, cetirizine hydrochloride, and loratadine tablets but had not experienced any relief in her condition. Thereafter, she was treated with oral traditional Chinese medicine. Her skin damage gradually improved within two months of treatment initiation. After six months, the skin ulcers had completely subsided. No evidence of skin ulcer recurrence was observed during the subsequent follow-up. This report presents the first case of a female patient who received oral Danggui Sini decoction for the treatment of ACV.


Danggui Sini decoction may be a promising oral treatment for ACV patients.

Keywords: Allergic cutaneous vasculitis, Danggui Sini decoction, Traditional Chinese Medicine, Ulcer, Rash, Case report

Core Tip: This is the first report of the recovery of skin ulcers in a patient with allergic cutaneous vasculitis (ACV) treated with Danggui Sini decoction. This finding indicates that Traditional Chinese Medicine is particularly effective in the treatment of ACV.