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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Diabetes and skin cancers: Risk factors, molecular mechanisms and impact on prognosis
Elena-Codruta Dobrică, Madalina Laura Banciu, Vincent Kipkorir, Mohammad Amin Khazeei Tabari, Madeleine Jemima Cox, L V Simhachalam Kutikuppala, Mihnea-Alexandru Găman
Elena-Codruta Dobrică, Doctoral School, University of Medicine and Pharmacy of Craiova, Craiova 200349, Romania
Madalina Laura Banciu, Department of Dermatology, "Elias" University Emergency Hospital, Bucharest 011461, Romania
Vincent Kipkorir, Department of Human Anatomy, University of Nairobi, College of Health Sciences, Nairobi 00100, Kenya
Mohammad Amin Khazeei Tabari, USERN Office, Mazandaran University of Medical Sciences, Sari 48175-866, Iran
Madeleine Jemima Cox, University of New South Wales, University of New South Wales, Sydney 2052, Australia
L V Simhachalam Kutikuppala, Dr NTR University of Health Sciences, Vijayawada, Andhra Pradesh 520008, India
Mihnea-Alexandru Găman, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest 050474, Romania
Author contributions: Dobrică EC, Banciu ML, Kipkorir V, Khazeei Tabari MA, Cox MJ, Simhachalam Kutikuppala LV, and Găman MA contributed to writing original draft; Găman MA contributed to writing, review & editing, and methodology; all authors read and approved the final version of this paper.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Mihnea-Alexandru Găman, Doctor, MD, PhD, Doctor, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd, Bucharest 050474, Romania. mihneagaman@yahoo.com
Received: June 16, 2022
Peer-review started: June 16, 2022
First decision: August 7, 2022
Revised: August 20, 2022
Accepted: September 21, 2022
Article in press: September 21, 2022
Published online: November 6, 2022
Diabetes and skin cancers have emerged as threats to public health worldwide. However, their association has been less intensively studied. In this narrative review, we explore the common risk factors, molecular mechanisms, and prognosis of the association between cutaneous malignancies and diabetes. Hyperglycemia, oxidative stress, low-grade chronic inflammation, genetic, lifestyle, and environmental factors partially explain the crosstalk between skin cancers and this metabolic disorder. In addition, diabetes and its related complications may interfere with the appropriate management of cutaneous malignancies. Antidiabetic medication seems to exert an antineoplastic effect, however, future large, observation studies with a prospective design are needed to clarify its impact on the risk of malignancy in diabetes. Screening for diabetes in skin cancers, as well as close follow-up for the development of cutaneous malignancies in subjects suffering from diabetes, is warranted.
Core Tip: Diabetes and skin cancers have emerged as threats to public health worldwide. However, their association has been less intensively studied. In this narrative review, we explore the common risk factors, molecular mechanisms and prognosis of the association between cutaneous malignancies and diabetes.
