Ghali M, Bensted K, Williams DB, Ghaly S. Type 2 autoimmune pancreatitis associated with severe ulcerative colitis: Three case reports. World J Clin Cases 2022; 10(24): 8788-8796 [PMID: 36157795 DOI: 10.12998/wjcc.v10.i24.8788]
Corresponding Author of This Article
Mark Ghali, MD, Doctor, Department of Gastroenterology, St Vincent's Hospital, No. 390 Victoria St, Darlinghurst 2010, NSW, Australia. markghali3@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Aug 26, 2022; 10(24): 8788-8796 Published online Aug 26, 2022. doi: 10.12998/wjcc.v10.i24.8788
Type 2 autoimmune pancreatitis associated with severe ulcerative colitis: Three case reports
Mark Ghali, Karen Bensted, David B Williams, Simon Ghaly
Mark Ghali, Karen Bensted, David B Williams, Simon Ghaly, Department of Gastroenterology, St Vincent's Hospital, Darlinghurst 2010, NSW, Australia
Mark Ghali, David B Williams, Simon Ghaly, School of Clinical Medicine, Faculty of Medicine and Health, The University of New South Wales, Sydney 1466, NSW, Australia
Author contributions: Williams DB and Ghaly S created the report design; Ghali M performed case note review and manuscript drafting; Ghali M, Bensted K, Williams DB and Ghaly S performed manuscript editing.
Informed consent statement: The written Informed consent was obtained from all patients.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mark Ghali, MD, Doctor, Department of Gastroenterology, St Vincent's Hospital, No. 390 Victoria St, Darlinghurst 2010, NSW, Australia. markghali3@gmail.com
Received: April 12, 2022 Peer-review started: April 12, 2022 First decision: May 12, 2022 Revised: May 31, 2022 Accepted: July 22, 2022 Article in press: July 22, 2022 Published online: August 26, 2022
Abstract
BACKGROUND
Type two autoimmune pancreatitis is a rare and difficult to diagnose, steroid responsive non-IgG4 inflammatory pancreatopathy that can be associated with inflammatory bowel disease.
CASE SUMMARY
This case series describes three cases with varied clinical presentations and re-presentations of autoimmune pancreatitis, and all associated with an aggressive course of ulcerative colitis. The pancreatopathy was independent of bowel disease activity and developed in one case following colectomy.
CONCLUSION
Clinician awareness about this condition is important to allow early diagnosis, treatment and avoid unnecessary pancreatic surgery.
Core Tip: Type two autoimmune pancreatitis is a rare and difficult to diagnose, steroid responsive non-IgG4 inflammatory pancreatopathy that can be associated with an aggressive course of ulcerative colitis but with independence from bowel disease activity. Clinician awareness about this condition is important to allow early diagnosis, treatment and avoid unnecessary pancreatic surgery.
