Mukherjee D, Krishnan A. Therapeutic potential of curcumin and its nanoformulations for treating oral cancer. World J Methodol 2023; 13(3): 29-45 [PMID: 37456978 DOI: 10.5662/wjm.v13.i3.29]
Corresponding Author of This Article
Arunkumar Krishnan, MBBS, Doctor, Department of Medicine Section of Gastroenterology and Hepatology, West Virginia University School of Medicine, PO Box 9161, 5th Floor HSC, Room 5500 Morgantown, WV 26505, United States. dr.arunkumar.krishnan@gmail.com
Research Domain of This Article
Oncology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Methodol. Jun 20, 2023; 13(3): 29-45 Published online Jun 20, 2023. doi: 10.5662/wjm.v13.i3.29
Therapeutic potential of curcumin and its nanoformulations for treating oral cancer
Diptasree Mukherjee, Arunkumar Krishnan
Diptasree Mukherjee, Department of Biochemistry, All India Institute of Medical Sciences, Bhubaneswar 751019, Odisha, India
Diptasree Mukherjee, Department of Medicine, Apex Institute of Medical Science, Kolkata 700075, West Bengal, India
Arunkumar Krishnan, Department of Medicine Section of Gastroenterology and Hepatology, West Virginia University School of Medicine, Morgantown, WV 26505, United States
Author contributions: Mukherjee D conceptualized and wrote the original draft; Krishnan A reviewed and edited the draft; and all authors revised the manuscript for important intellectual content and approved the article’s final version.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Noncommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Arunkumar Krishnan, MBBS, Doctor, Department of Medicine Section of Gastroenterology and Hepatology, West Virginia University School of Medicine, PO Box 9161, 5th Floor HSC, Room 5500 Morgantown, WV 26505, United States. dr.arunkumar.krishnan@gmail.com
Received: December 13, 2022 Peer-review started: December 13, 2022 First decision: February 8, 2023 Revised: March 14, 2023 Accepted: April 14, 2023 Article in press: April 14, 2023 Published online: June 20, 2023
Core Tip
Core Tip: Oral cancer has a high disease burden worldwide. Oral squamous cell carcinoma is the most predominant subtype of oral cancer. The majority of oral cancers present at an advanced stage and are associated with a poor prognosis. Timely diagnosis and early treatment are critical to achieve a superior outcome. Surgery is the recommended treatment for oral cancer; other treatment modalities are radiotherapy with or without chemotherapy. Curcumin, a plant derivative, is one among the available adjuvant therapies that has been studied for its anticarcinogenic potential in the setting of various cancers. Curcumin has been proven to modulate intracellular signaling pathways that control cancer cell growth, inflammation, invasion, apoptosis, and cell death, with evidence supporting its use in cancer therapy. This review aims to summarize the molecular pathways involved in oral carcinoma pathogenesis, to explore different therapeutic interactions of curcumin, and to highlight the role of novel curcumin formulations in oral cancer treatment.
