Systematic Reviews
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Methodol. Nov 20, 2022; 12(6): 476-487
Published online Nov 20, 2022. doi: 10.5662/wjm.v12.i6.476
Associations between SARS-CoV-2 infections and thrombotic complications necessitating surgical intervention: A systematic review
Jennifer J Ferraro, Allie Reynolds, Sylvia Edoigiawerie, Michelle Y Seu, Sydney R Horen, Amir Aminzada, Alireza Hamidian Jahromi
Jennifer J Ferraro, Michelle Y Seu, Sydney R Horen, Amir Aminzada, Division of Plastic and Reconstructive Surgery, Department of Surgery, Rush University Medical Center, Chicago, IL 60612, United States
Allie Reynolds, Sylvia Edoigiawerie, Medical School, University of Chicago, Chicago, IL 60637, United States
Alireza Hamidian Jahromi, Department of Surgery, Temple University Hospital, Philadelphia, PA 19140, United States
Author contributions: Hamidian Jahromi A contributed to conceptualization and manuscript editing; Ferraro JJ, Reynolds A, Edoigiawerie S, Seu MY, Horen SR, and Aminzada A contributed to writing, statistical analysis, and manuscript editing.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Alireza Hamidian Jahromi, MD, Assistant Professor, Doctor, Department of Surgery, Temple University Hospital, 3401 N. Broad Street, Parkinson Pavilion, Suite 400, Philadelphia, PA 19140, United States.
Received: April 15, 2022
Peer-review started: April 15, 2022
First decision: August 1, 2022
Revised: September 1, 2022
Accepted: November 4, 2022
Article in press: November 4, 2022
Published online: November 20, 2022
Core Tip

Core Tip: Surgical patient with a history of or current active infection with severe acute respiratory syndrome coronavirus 2 bear a significantly high risk for postoperative thrombotic complications. These patients may require surgical intervention to treat severe thrombotic complications. In total, 70 cases of thromboembolic complications necessitating surgical intervention have been documented. These patients have an overall mortality rate of 30%. Intestinal ischemia and acute limb ischemia are the most common thrombotic complications that required operative management. Physicians should be aware that severe thrombotic complications can occur in this patient population, however, surgical intervention results in relatively low mortality apart from cases of ischemic bowel resection.