Systematic Reviews
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Methodol. May 20, 2022; 12(3): 122-131
Published online May 20, 2022. doi: 10.5662/wjm.v12.i3.122
Single-use duodenoscopes for the prevention of endoscopic retrograde cholangiopancreatography -related cross-infection – from bench studies to clinical evidence
Andrea Lisotti, Pietro Fusaroli, Bertrand Napoleon, Anna Cominardi, Rocco Maurizio Zagari
Andrea Lisotti, Pietro Fusaroli, Anna Cominardi, Gastroenterology Unit, Hospital of Imola, University of Bologna, Imola 40026, BO, Italy
Bertrand Napoleon, Gastroenterology Unit, Hôpital privé Jean Mermoz - Ramsay Générale de Santé, Lyon 69008, FR, France
Rocco Maurizio Zagari, Dipertimento Di Scienze Mediche e Chirurgiche, Università di Bologna, Policlinico San Orsola Malpighi, Bologna 40138, Italy
Author contributions: Lisotti A and Fusaroli P wrote the paper; Napoléon B, Cominardi A and Zagari RM performed data collection for systematic review; all authors reviewed manuscript for pivotal intellectual content.
Conflict-of-interest statement: Authors declare no conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Andrea Lisotti, MD, MSc, Adjunct Professor, Gastroenterology Unit, Hospital of Imola, University of Bologna, via Montericco 4, Imola 40026, BO, Italy.
Received: November 28, 2021
Peer-review started: November 28, 2021
First decision: January 12, 2022
Revised: January 16, 2022
Accepted: March 16, 2022
Article in press: March 16, 2022
Published online: May 20, 2022
Core Tip

Core Tip: Endoscopic retrograde cholangiopancreatography (ERCP) has significantly changed the management and natural history of patients with biliary and pancreatic diseases. While in the past decades ERCP procedure were considered safe and bearing low-risk for exogenous pathogens transmission, the risk of duodenoscopes contaminations and related cross-infection was recently demonstrated and quantified. To overcome this issue, two different single-use duodenoscopes (SUD) have been developed and are commercially available. The sterile packaging and the disposable intent guarantee to avoid exogenous patient-to-patient cross-infections. A systematic review of all available clinical evidence on the use of SUD for ERCP was performed, demonstrating an overall pooled safety and efficacy. Although few clinical trials are available, evidence is concordant in identifying an absolute feasibility and safety and feasibility for single-use duodenoscopes (SUD) use for ERCP. Future large clinical trials are ongoing to increase the knowledge and quality of evidence in the field; data on cost-effectiveness and environmental impact will be needed for a worldwide spread of SUD use for ERCP.