Retrospective Cohort Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Nephrol. Sep 6, 2016; 5(5): 437-447
Published online Sep 6, 2016. doi: 10.5527/wjn.v5.i5.437
Parathyroid ultrasonography and bone metabolic profile of patients on dialysis with hyperparathyroidism
Cláudia Ribeiro, Maria Goretti Moreira Guimarães Penido, Milena Maria Moreira Guimarães, Marcelo de Sousa Tavares, Bruno das Neves Souza, Anderson Ferreira Leite, Leonardo Martins Caldeira de Deus, Lucas José de Campos Machado
Cláudia Ribeiro, Center of Nephrology, Santa Casa de Belo Horizonte Hospital, Belo Horizonte CEP 30150320, Minas Gerais, Brazil
Maria Goretti Moreira Guimarães Penido, Marcelo de Sousa Tavares, Pediatric Nephrology Unit, School of Medicine, Federal University of Minas Gerais, Belo Horizonte CEP 30130100, Minas Gerais, Brazil
Maria Goretti Moreira Guimarães Penido, Marcelo de Sousa Tavares, Pediatric Nephrology Unit, Center of Nephrology, Santa Casa de Belo Horizonte Hospital, Belo Horizonte CEP 30150320, Minas Gerais, Brazil
Milena Maria Moreira Guimarães, Lucas José de Campos Machado, Department of Internal Medicine, School of Medicine, Federal University of Minas Gerais, Belo Horizonte CEP 30130100, Minas Gerais, Brazil
Bruno das Neves Souza, Leonardo Martins Caldeira de Deus, School of Medicine, Federal University of Minas Gerais, Belo Horizonte CEP 30130100, Minas Gerais, Brazil
Anderson Ferreira Leite, Department of Cardiology, Clinic Hospital, Federal University of Minas Gerais, Belo Horizonte CEP 30130100, Minas Gerais, Brazil
Author contributions: Ribeiro C, Penido MGMG, Guimarães MMM, Tavares MS and Machado LJC contributed equally to the conception and design of the study, the acquisition, analysis and interpretation of data, and the drafting and critical revision of the article; Souza BN, Leite AF and de Deus LMC performed the research and analyzed the data.
Institutional review board statement: The study was reviewed and approved by the Research Ethics Committee of the Graduation Center of Santa Casa de Belo Horizonte, MG (011/2005).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment and it was performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki.
Conflict-of-interest statement: The authors (Cláudia Ribeiro, Maria Goretti Moreira Guimarães Penido, Milena Maria Moreira Guimarães, Bruno das Neves Souza, Leonardo Martins Caldeira de Deus, Anderson Ferreira Leite, Marcelo de Sousa Tavares and Lucas José de Campos Machado) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at mariagorettipenido@yahoo.com.br. Participants gave informed consent for data sharing and the presented data are anonymized. There is no risk of identification.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Maria Goretti Moreira Guimarães Penido, MD, PhD, Coordinator, Pediatric Nephrology Unit, Center of Nephrology, Santa Casa de Belo Horizonte Hospital, Rua Piaui 420, Belo Horizonte CEP 30150320, Minas Gerais, Brazil. mariagorettipenido@yahoo.com.br
Telephone: +55-31-99291595 Fax: +55-31-32414466
Received: January 28, 2016
Peer-review started: January 28, 2016
First decision: March 23, 2016
Revised: May 14, 2016
Accepted: June 27, 2016
Article in press: June 29, 2016
Published online: September 6, 2016
Core Tip

Core tip: We aimed to evaluate the parathyroid ultrasonography and defined parameters to predict poor response to treatment in 85 patients with chronic kidney disease stage V and parathyroid hormone (PTH) levels > 800 pg/mL. Fifty-three patients had nodules, higher PTH, calcium and phosphorus. Sixteen underwent parathyroidectomy and had significant higher levels of phosphorus and calcium phosphorus product; lower mortality and lower incidence of cardiovascular or cerebrovascular events. Calcium phosphorus product above 55, vascular calcification and previous vascular events were risk factors for mortality. There was no association between nodules and mortality. We concluded that nodules at ultrasonography strengthens the indication for parathyroidectomy in those patients.