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World J Nephrol. May 6, 2015; 4(2): 307-312
Published online May 6, 2015. doi: 10.5527/wjn.v4.i2.307
Species differences in regulation of renal proximal tubule transport by certain molecules
George Seki, Motonobu Nakamura, Masashi Suzuki, Nobuhiko Satoh, Shoko Horita
George Seki, Motonobu Nakamura, Masashi Suzuki, Nobuhiko Satoh, Shoko Horita, Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan
Author contributions: All the authors contributed to writing of this manuscript.
Conflict-of-interest: None.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: George Seki, MD, Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. georgeseki-tky@umin.ac.jp
Telephone: +81-3-38155411 Fax: +81-3-58008806
Received: November 26, 2014
Peer-review started: November 27, 2014
First decision: December 18, 2014
Revised: December 24, 2014
Accepted: January 18, 2015
Article in press: January 20, 2015
Published online: May 6, 2015
Core Tip

Core tip: Renal proximal tubule (PT) transport is essential for the regulation of plasma volume and blood pressure. Several species differences are found as to the stimulatory effects of thiazolidinediones, insulin, and angiotensin II on PT sodium transport. This review focuses on this topic, which may be relevant to species-specific mechanisms underlying edema formation and/or hypertension occurrence.