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World J Nephrol. May 6, 2013; 2(2): 17-25
Published online May 6, 2013. doi: 10.5527/wjn.v2.i2.17
Uric acid and chronic kidney disease: A time to act?
Gianni Bellomo
Gianni Bellomo, Department of Nephrology, San Giovanni Battista Hospital, 06034 Foligno, Italy
Author contributions: Bellomo G solely contributed to this manuscript.
Correspondence to: Gianni Bellomo, MD, Department of Nephrology, San Giovanni Battista Hospital, Via Arcamone 1, 06034 Foligno, Italy. assidial@tin.it
Telephone: +39-742-3397083 Fax: +39-742-3397083
Received: February 7, 2013
Revised: March 25, 2013
Accepted: April 10, 2013
Published online: May 6, 2013
Core Tip

Core tip: The evidence presented so far, derived from experimental, epidemiological, and a few, small, intervention studies, points towards a role for uric acid in the progression of chronic kidney disease and deterioration of renal function. However, conclusive proof, such as that coming from a randomized clinical trial, is lacking. Finally we will briefly discuss the challenges of a trial of uric-acid-lowering treatment, and the recent suggestions on how to conduct such a trial.