Published online May 6, 2013. doi: 10.5527/wjn.v2.i2.17
Revised: March 25, 2013
Accepted: April 10, 2013
Published online: May 6, 2013
Core tip: The evidence presented so far, derived from experimental, epidemiological, and a few, small, intervention studies, points towards a role for uric acid in the progression of chronic kidney disease and deterioration of renal function. However, conclusive proof, such as that coming from a randomized clinical trial, is lacking. Finally we will briefly discuss the challenges of a trial of uric-acid-lowering treatment, and the recent suggestions on how to conduct such a trial.