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World J Virol. Nov 12, 2013; 2(4): 160-169
Published online Nov 12, 2013. doi: 10.5501/wjv.v2.i4.160
Published online Nov 12, 2013. doi: 10.5501/wjv.v2.i4.160
Evolution of an avian H5N1 influenza A virus escape mutant
Kamel M A Hassanin, Biochemistry Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, Egypt
Ahmed S Abdel-Moneim, Virology Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, Egypt
Ahmed S Abdel-Moneim, Microbiology Department, Virology Division, College of Medicine, Taif University, Al-Taif 21944, Makkah Province, Saudi Arabia
Author contributions: Both authors contributed to this work.
Correspondence to: Ahmed S Abdel-Moneim, Professor of Virology, Virology Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, Egypt. asa@bsu.edu.eg
Telephone: +20-82-2327982 Fax: +20-82-2327982
Received: June 29, 2013
Revised: August 21, 2013
Accepted: September 14, 2013
Published online: November 12, 2013
Revised: August 21, 2013
Accepted: September 14, 2013
Published online: November 12, 2013
Core Tip
Core tip: The evolution of phylogenetic trees of different viral genes revealed the absence of reassortment in the examined escape mutant H5N1 strain; however, a variety of amino acid substitutions were recorded. The displayed amino acids substitutions in different viral alleles denoted considerable possibility of inter-species transmission, virulence to mammalian species and cytokine resistance.