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World J Virol. Nov 12, 2013; 2(4): 146-151
Published online Nov 12, 2013. doi: 10.5501/wjv.v2.i4.146
Published online Nov 12, 2013. doi: 10.5501/wjv.v2.i4.146
Impact of PRRSV on activation and viability of antigen presenting cells
Irene M Rodríguez-Gómez, Librado Carrasco, Department of Anatomy and Comparative Pathology, University of Córdoba, 14071 Córdoba, Spain
Jaime Gómez-Laguna, CICAP - Food Research Centre, Pozoblanco, 14400 Córdoba, Spain
Author contributions: Rodríguez-Gómez IM, Gómez-Laguna J and Carrasco L contributed to this paper.
Supported by The Spanish Ministry of Education and Science, No. AGL2009-12438/GAN
Correspondence to: Irene M Rodríguez-Gómez, DVM, PhD, Department of Anatomy and Comparative Pathology, University of Córdoba, Ctra. Madrid-Cádiz, Km. 396, 14071 Córdoba, Spain. v22rogoi@uco.es
Telephone: +34-957-218162 Fax: +34-957-218682
Received: June 26, 2013
Revised: September 9, 2013
Accepted: October 16, 2013
Published online: November 12, 2013
Revised: September 9, 2013
Accepted: October 16, 2013
Published online: November 12, 2013
Core Tip
Core tip: Porcine reproductive and respiratory syndrome virus (PRRSV) is able to evade the host immune response and survive in the organism causing transient infections. PRRSV interacts with antigen presenting cells, specifically with dendritic cells, causing a regulation of major histocompatibility complex class II and/or CD80/86 and cell death by apoptosis and/or necrosis.