Copyright
©2013 Baishideng. All rights reserved.
Paramyxovirus evasion of innate immunity: Diverse strategies for common targets
Michelle D Audsley, Gregory W Moseley, Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia
Author contributions: Audsley MD and Moseley GW solely contributed to this paper.
Correspondence to: Dr. Gregory W Moseley, Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Victoria 3800, Australia. greg.moseley@monash.edu
Telephone: +61-3-99029354 Fax: +61-3-99029500
Received: December 5, 2012
Revised: February 14, 2013
Accepted: April 9, 2013
Published online: May 12, 2013
Revised: February 14, 2013
Accepted: April 9, 2013
Published online: May 12, 2013
Core Tip
Core tip: The paramyxoviruses are a family of > 30 viruses that variously infect humans, other mammals and fish to cause diverse outcomes, ranging from asymptomatic to lethal disease, with the zoonotic paramyxoviruses Nipah and Hendra showing up to 70% case-fatality rate in humans. Here, we review the interferon antagonism strategies of paramyxoviruses, highlighting mechanistic differences observed between individual species and genera. We also discuss potential sources of this diversity, including biological differences in the host and/or tissue specificity of different paramyxoviruses, and potential effects of experimental approaches that have largely relied on in vitro systems.