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World J Virol. Mar 25, 2023; 12(2): 91-99
Published online Mar 25, 2023. doi: 10.5501/wjv.v12.i2.91
The impact of COVID-19 on liver injury in various age
Amin Sadeghi Dousari, Seyed Soheil Hosseininasab, Fatemeh Sadeghi Dousari, Masoumeh Fuladvandi, Naghmeh Satarzadeh
Amin Sadeghi Dousari, Department of Microbiology, Jiroft University of Medical Sciences, Jiroft 7861634204, Iran
Seyed Soheil Hosseininasab, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman 7616913555, Iran
Fatemeh Sadeghi Dousari, Department of Midwifery, Jiroft University of Medical Sciences, Jiroft 7861634204, Iran
Masoumeh Fuladvandi, Department of Nursing, Aligoudarz School of Nursing, Lorestan University of Medical Sciences, Khorramabad 6813833946, Iran
Naghmeh Satarzadeh, Department of Pharmaceutical Biotechnology, Kerman University of Medical Sciences, Kerman 7616913555, Iran
Author contributions: Sadeghi Dousari A, Hosseininasab SS, Sadeghi Dousari F, Fuladvandi M, Satarzadeh N analyzed the data and wrote the manuscript; All authors have read and approve the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Naghmeh Satarzadeh, PhD, Researcher, Department of Pharmaceutical Biotechnology, Kerman University of Medical Sciences, Haft-Bagh Highway, Kerman 7616913555, Iran.
Received: September 13, 2022
Peer-review started: September 13, 2022
First decision: September 29, 2022
Revised: October 14, 2022
Accepted: January 3, 2023
Article in press: January 3, 2023
Published online: March 25, 2023

The coronavirus disease 2019 (COVID-19) disease was first detected in December 2019 in Wuhan, China. This disease is currently one of the most important global health problems. The novel coronavirus COVID-19 is a respiratory illness, that has caused a deadly pandemic that is spreading rapidly around the world. It is not only a respiratory system virus that causes severe lung disease, but also a systemic disease agent that can affect all systems. People with COVID-19 disease usually have respiratory signs, however, the liver disorder is not an uncommon presentation. In addition, many studies around the world have revealed that the liver is injured to various degrees in patients with severe acute respiratory syndrome coronavirus 2 disease. This review mainly focuses on the impact of COVID-19 on Liver Injury at various ages.

Keywords: Liver injury, Coronavirus disease 2019, Severe acute respiratory syndrome coronavirus 2, Minireview

Core Tip: Studies have shown that neonates have rare evidence of liver damage, and in terms of age, they show the least amount of liver damage in the face of coronavirus disease 2019 (COVID-19) among affected people. Also, many studies reported different patterns of liver damage among children with COVID-19 much less than in adults, which is probably related to differences in their innate immune system and adaptation. The highest rate of liver damage is in adult patients and aspartate aminotransferase levels had the highest relevance with mortality compared to other indices reflecting liver injury.