Beig M, Mohammadi M, Nafe Monfared F, Nasereslami S. Monkeypox: An emerging zoonotic pathogen. World J Virol 2022; 11(6): 426-434 [PMID: 36483104 DOI: 10.5501/wjv.v11.i6.426]
Corresponding Author of This Article
Mehrdad Mohammadi, PhD, Researcher, Department of Immunology and Microbiology, Faculty of Medicine, Kashan University of Medical Sciences, Ghoteb-e-ravandi Street, Kashan 8715973449, Iran. mehrdad.mohammadi1984@gmail.com
Research Domain of This Article
Virology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Masoumeh Beig, Department of Microbiology, Pasteur Institute of Iran, Tehran 5423566512, Iran
Mehrdad Mohammadi, Department of Immunology and Microbiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan 8715973449, Iran
Fatemeh Nafe Monfared, Department of Virology, Tehran University of Medical Sciences, Tehran 5151561892, Iran
Somaieh Nasereslami, Department of Virology, Faculty of Medicine, Tarbiat Modares University, Tehran 5214632542, Iran
Author contributions: Beig M, Mohammadi M, Nafe Monfared F, and Nasereslami S were the study's principal investigators; Beig M and Mohammadi M were involved in the concept and design of the study; Mohammadi M and Nasereslami S revised the manuscript and critically evaluated the intellectual content; All authors participated in preparing the final draft of the manuscript, revised the manuscript, and critically assessed the academic ranges; All authors have read and approved the manuscript's content and confirmed the accuracy or integrity of any part of the work.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mehrdad Mohammadi, PhD, Researcher, Department of Immunology and Microbiology, Faculty of Medicine, Kashan University of Medical Sciences, Ghoteb-e-ravandi Street, Kashan 8715973449, Iran. mehrdad.mohammadi1984@gmail.com
Received: June 5, 2022 Peer-review started: June 5, 2022 First decision: August 1, 2022 Revised: August 22, 2022 Accepted: October 12, 2022 Article in press: October 12, 2022 Published online: November 25, 2022
Abstract
Monkeypox virus (MPXV), which belongs to the orthopoxvirus genus, causes zoonotic viral disease. This review discusses the biology, epidemiology, and evolution of MPXV infection, particularly cellular, human, and viral factors, virus transmission dynamics, infection, and persistence in nature. This review also describes the role of recombination, gene loss, and gene gain in MPXV evol-vement and the role of signal transduction in MPXV infection and provides an overview of the current access to therapeutic options for the treatment and prevention of MPXV. Finally, this review highlighted gaps in knowledge and proposed future research endeavors to address the unresolved questions.
Core Tip: Since May 13, 2022, cases of monkeypox have been reported to the World Health Organization (WHO) from 12 Member States that are not endemic to the monkeypox virus across three WHO regions. This emergent pathogen is a significant concern worldwide after severe acute respiratory syndrome coronavirus 2 and requires epidemiological and other data on the virus. The objective of this review is to report comprehensive data on this virus.
